ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Dynamic and permissive roles of TRPV1 and TRPV4 channels for thermosensation in mouse supraoptic magnocellular neurosecretory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firing.Stem cell research & therapy · 2026Article
- The neural thermostat malfunction: revisiting heatstroke through the lens of warm-sensitive neuron dysregulation.Frontiers in cellular neuroscience · 2026Review
- Role of TRPV1 in neuroendocrine regulation: a potential target against obesity?Frontiers in immunology · 2025Review
- Inflammation and vasopressin hypersecretion in aging.Frontiers in endocrinology · 2025Review
- Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?Physiology (Bethesda, Md.) · 2024Review
- TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus.Nutrients · 2022Article
- Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease.Frontiers in cellular neuroscience · 2022Review
- Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center.Pflugers Archiv : European journal of physiology · 2018Review
- Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake.PLoS biology · 2018Article
- Osmotic activation of a CaPhysiological reports · 2017Article
- Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Science signaling · 2016Article
- Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons Mediating Thirst and Vasopressin Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Molecular mechanisms of temperature adaptation.The Journal of physiology · 2015Review
- Computed ABC Analysis for Rational Selection of Most Informative Variables in Multivariate Data.PloS one · 2015Article
- Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress.Channels (Austin, Tex.) · 2015Article
- Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Article
- Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- TRP ion channels in thermosensation, thermoregulation and metabolism.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The transient receptor potential vanilloid 1 and 4 genes (trpv1, trpv4) encode temperature-sensitive cation channels hypothesized to mediate thermoresponses in mammalian cells. Although such channels were shown to participate in the peripheral detection of ambient temperature, the specific roles of these channels in central thermosensory neurons remain unclear. Here we report that the membrane potential and excitability of mouse magnocellular neurosecretory cells (MNCs) maintained at physiological temperature were lowered in an additive manner upon pharmacological blockade, or genetic deletion, of trpv1 and trpv4. However extracellular recordings from spontaneously active MNCs in situ showed that blockade or genetic deletion of trpv4 does not interfere with thermally induced changes in action potential firing, whereas loss of trpv1 abolished this phenotype. These findings indicate that channels encoded by trpv4 play a permissive role that contributes to basal electrical activity, but that trpv1 plays a dynamic role that is required for physiological thermosensation by MNCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.