ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Strabismus disrupts binocular synaptic integration in primary visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
- Acuity-independent effects of visual deprivation on human visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Device closure of a small atrial septal defect with an unusual set of post-operative complications.BMC cardiovascular disorders · 2026Article
- Adaptive, social, and repetitive behaviors in children with autism spectrum disorder and comorbid amblyopia and/or strabismus.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026Article
- A Critical Look at Critical Periods.Annual review of vision science · 2025Review
- Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.Experimental & molecular medicine · 2025Article
- Non-Invasive Recording of Ocular-Following Responses in Children: A Promising Tool for Stereo Deficiency Evaluation.Journal of clinical medicine · 2024Article
- Flash Suppression Reveals an Additional Nonvisual Extrastriate Contribution for Amblyopic Suppression.Investigative ophthalmology & visual science · 2024Article
- EEG measurement for the effect of perceptual eye position and eye position training on comitant strabismus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia.Zoological research · 2023Article
- Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia.Investigative ophthalmology & visual science · 2023Article
- A binocular synaptic network supports interocular response alignment in visual cortical neurons.Neuron · 2022Article
- Abnormal cortical morphology in children and adolescents with intermittent exotropia.Frontiers in neuroscience · 2022Article
- Study of Geometric Illusory Visual Perception - A New Perspective in the Functional Evaluation of Children With Strabismus.Frontiers in human neuroscience · 2022Article
- A novel theoretical framework for simultaneous measurement of excitatory and inhibitory conductances.PLoS computational biology · 2021Article
- Interocular suppression in primary visual cortex in strabismus: impact of staggering the presentation of stimuli to the eyes.Journal of neurophysiology · 2021Article
- Interocular Suppression in Primary Visual Cortex in Strabismus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Changes in the Brain Activity and Visual Performance of Patients with Strabismus and Amblyopia after a Compete Cycle of Light Therapy.Brain sciences · 2021Article
- Sequential perceptual learning of letter identification and "uncrowding" in normal peripheral vision: Effects of task, training order, and cholinergic enhancement.Journal of vision · 2020Article
- Article
- Characterization of Intelligence in Children with Exotropia.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Visual disruption early in development dramatically changes how primary visual cortex neurons integrate binocular inputs. The disruption is paradigmatic for investigating the synaptic basis of long-term changes in cortical function, because the primary visual cortex is the site of binocular convergence. The underlying alterations in circuitry by visual disruption remain poorly understood. Here we compare membrane potential responses, observed via whole-cell recordings in vivo, of primary visual cortex neurons in normal adult cats with those of cats in which strabismus was induced before the developmental critical period. In strabismic cats, we observed a dramatic shift in the ocular dominance distribution of simple cells, the first stage of visual cortical processing, toward responding to one eye instead of both, but not in complex cells, which receive inputs from simple cells. Both simple and complex cells no longer conveyed the binocular information needed for depth perception based on binocular cues. There was concomitant binocular suppression such that responses were weaker with binocular than with monocular stimulation. Our estimates of the excitatory and inhibitory input to single neurons indicate binocular suppression that was not evident in synaptic excitation, but arose de novo because of synaptic inhibition. Further constraints on circuit models of plasticity result from indications that the ratio of excitation to inhibition evoked by monocular stimulation decreased mainly for nonpreferred eye stimulation. Although we documented changes in synaptic input throughout primary visual cortex, a circuit model with plasticity at only thalamocortical synapses is sufficient to account for our observations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.