ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Activation of axonal receptors by GABA spillover increases somatic firing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Signal switching may enhance processing power of the brain.Trends in cognitive sciences · 2024Review
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- Antidromic Analog Signaling.Frontiers in cellular neuroscience · 2019Review
- Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity.Frontiers in cellular neuroscience · 2019Review
- Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings.Frontiers in cellular neuroscience · 2019Review
- Activity-dependent plasticity of presynaptic GABASynapse (New York, N.Y.) · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Axonal GABAThe Journal of physiology · 2017Article
- FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon.Nature communications · 2016Article
- Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABAA and GABAB receptors in mice.The Journal of physiology · 2016Article
- Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.The Journal of general physiology · 2015Article
- An excitatory GABA loop operating in vivo.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Axons can be depolarized by ionotropic receptors and transmit subthreshold depolarizations to the soma by passive electrical spread. This raises the possibility that axons and axonal receptors can participate in integration and firing in neurons. Previously, we have shown that exogenous GABA depolarizes cerebellar granule cell axons through local activation of GABA(A) receptors (GABA(A)Rs) and the soma through electrotonic spread of the axonal potential resulting in increased firing. We show here that excitability of granule cells is also increased by release of endogenous GABA from molecular layer interneurons (MLIs) and spillover activation of parallel fiber GABA(A)Rs in mice and rats. Changes in granule cell excitability were assessed by excitability testing after activation of MLIs with channelrhodopsin or electrical stimulation in the molecular layer. In granule cells lacking an axon, excitability was not changed, suggesting that axonal receptors are required. To determine the distance over which subthreshold potentials may spread, we estimated the effective axonal electrical length constant (520 μm) by excitability testing and focal uncaging of RuBi-GABA on the axon at varying distances from the soma. These data suggest that GABA(A)R-mediated axonal potentials can participate in integration and firing of cerebellar granule cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.