ArticleJournal of dental research2014
Contribution of mesenchymal proliferation in tooth root morphogenesis.
Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Loss of Stat3 in OsterixCell & bioscience · 2023Article
- The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction-diffusion system.Scientific reports · 2021Article
- Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning.PLoS genetics · 2021Article
- Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.Development (Cambridge, England) · 2021Article
- Signaling Modulation byFrontiers in cell and developmental biology · 2021Article
- Expression of Different Isoforms of Versican During the Development of Mouse Mandibular First Molars.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Article
- The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology.The Journal of biological chemistry · 2019Article
- Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.Journal of molecular histology · 2017Article
- Regulation of root patterns in mammalian teeth.Scientific reports · 2017Article
- The Impact of the Eda Pathway on Tooth Root Development.Journal of dental research · 2017Article
- Cellular and molecular mechanisms of tooth root development.Development (Cambridge, England) · 2017Review
- The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.Histochemistry and cell biology · 2015Article
- Nfic regulates tooth root patterning and growth.Anatomy & cell biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mouse tooth development, the roots of the first lower molar develop after crown formation to form 2 cylindrical roots by post-natal day 5. This study compared the morphogenesis and cellular events of the mesial-root-forming (MRF) and bifurcation-forming (BF) regions, located in the mesial and center of the first lower molar, to better define the developmental mechanisms involved in multi-rooted tooth formation. We found that the mesenchyme in the MRF showed relatively higher proliferation than the bifurcation region. This suggested that spatially regulated mesenchymal proliferation is required for creating cylindrical root structure. The mechanism may involve the mesenchyme forming a physical barrier to epithelial invagination of Hertwig's epithelial root sheath. To test these ideas, we cultured roots in the presence of pharmacological inhibitors of microtubule and actin polymerization, nocodazole and cytochalasin-D. Cytochalasin D also inhibits proliferation in epithelium and mesenchyme. Both drugs resulted in altered morphological changes in the tooth root structures. In particular, the nocodazole- and cytochalasin-D-treated specimens showed a loss of root diameter and formation of a single-root, respectively. Immunolocalization and three-dimensional reconstruction results confirmed these mesenchymal cellular events, with higher proliferation in MRF in multi-rooted tooth formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.