ArticleReproductive sciences (Thousand Oaks, Calif.)2014
Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation†.Biology of reproduction · 2025Article
- Maternal Diet-Induced Excess Adiposity in Mice Disrupts Mid-Gestation Decidual Immune and Vascular Homeostasis Without Impairing Spiral Artery Remodeling.Acta physiologica (Oxford, England) · 2025Article
- Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial.International journal of fertility & sterility · 2025Article
- The Interplay of Uterine Health and Obesity: A Comprehensive Review.Biomedicines · 2024Review
- Placental adaptations supporting fetal growth during normal and adverse gestational environments.Experimental physiology · 2023Review
- Reliability of Rodent and Rabbit Models in Preeclampsia Research.International journal of molecular sciences · 2022Review
- Monocytes and macrophages in pregnancy: The good, the bad, and the ugly.Immunological reviews · 2022Review
- Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat.International journal of molecular sciences · 2022Review
- A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells.Frontiers in toxicology · 2022Article
- Delta-9-tetrahydrocannabinol inhibits invasion of HTR8/SVneo human extravillous trophoblast cells and negatively impacts mitochondrial function.Scientific reports · 2021Article
- Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1.Molecular human reproduction · 2020Article
- Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation.International journal of molecular sciences · 2020Review
- Maternal stressors and the developmental origins of neuropsychiatric risk.Frontiers in neuroendocrinology · 2020Review
- Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis.Nutrients · 2020Article
- Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation.Scientific reports · 2019Article
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific.European journal of nutrition · 2019Article
- Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.American journal of hypertension · 2017Article
- Maternal obesity drives functional alterations in uterine NK cells.JCI insight · 2016Article
- Quantifying trophoblast migration: In vitro approaches to address in vivo situations.Cell adhesion & migration · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Maternal obesity is associated with an increased risk of a number of pregnancy complications, including fetal demise, which may be linked to impaired placental development as a result of altered trophoblast invasion and vessel remodeling. Therefore, we examined these parameters in pregnant rats fed a control (normal weight) or high fat (HF) diet (obese) at 2 critical times of rat placental development. Early trophoblast invasion was increased by approximately 2-fold in HF-fed dams with a concomitant increase in the expression of matrix metalloproteinase 9 protein, a mediator of tissue remodeling and invasion. Furthermore, we observed significantly higher levels of smooth muscle actin surrounding the placental spiral arteries of HF-fed dams, suggesting impaired spiral artery remodeling. Taken together, the results of this study suggest that altered placental development is an important contributor to the poor pregnancy outcomes and increased fetal demise in our model of lifelong maternal obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.