ArticlePediatric blood & cancer2014
Neoplastic causes of abnormal puberty.
Article in Pediatric blood & cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy.ACS applied bio materials · 2024Review
- Adrenocortical carcinoma: Pediatric aspects (Review).Experimental and therapeutic medicine · 2022Review
- A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature.Neurology international · 2021Article
- [Clinical guidelines «Precocious puberty»].Problemy endokrinologii · 2021Article
- Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl.Case reports in pediatrics · 2019Article
- Fractures in children with newly diagnosed hepatoblastoma.Pediatric radiology · 2018Article
- Gene expression profiling of puberty-associated genes reveals abundant tissue and sex-specific changes across postnatal development.Human molecular genetics · 2017Article
- Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty.Annals of pediatric endocrinology & metabolism · 2016Article
- Male patients presenting with rapidly progressive puberty associated with malignant tumors.Annals of pediatric endocrinology & metabolism · 2016Article
- A Case Report of Adrenocortical Adenoma Mimicking Congenital Adrenal Hyperplasia in a Young Girl.Medicine · 2015Article
- Hepatoblastoma with Precocious Puberty.Journal of Indian Association of Pediatric SurgeonsArticle
- ADRENAL CARCINOMA IN CHILDREN: LONGITUDINAL STUDY IN MINAS GERAIS, BRAZIL.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloArticle
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeoplasm-related precocious puberty (PP) is a rare presenting feature of childhood cancer. Moreover, evaluation of suspected PP in a child is complex, and cancer is often not considered. We characterized the clinicopathologic features of patients presenting with PP at a large pediatric cancer center, reviewed the relevant literature, and developed an algorithm for the diagnostic work-up of these patients.
methodsWe examined the records of all patients with a neoplasm and concomitant PP treated at St. Jude Children's Research Hospital from January 1975 through October 2011, reviewed the available literature, and analyzed the demographic, clinical, endocrine, and neoplasm-related features.
resultsTwenty-four of 13,615 children and adolescents (0.18%) were diagnosed with PP within 60 days of presentation. Primary diagnoses included brain tumor (12), adrenocortical carcinoma (5), hepatoblastoma (4), and others (3). PP was observed 0-48 months before diagnosis of neoplasm; 17 patients had peripheral PP and 7 had central PP.
conclusionsNeoplasm-related PP is rare and takes the form of a paraneoplastic syndrome caused by tumor production of hormones or by alteration of physiologic gonadotropin production. PP can precede diagnosis of malignancy by months or years, and neoplastic causes should be considered early to avoid delayed cancer diagnosis. Treatment of the primary malignancy resolved or diminished PP in surviving patients with an intact hypothalamic-pituitary-gonadal axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.