Evidence map›Paper›PMID 24154816›Full record

ReviewInternational immunology2013

T cells in atherosclerosis.

Kevin Tse, Harley Tse, John Sidney, Alex Sette, Klaus Ley

Open access · greenAbstract readReview
In one paragraph

Review in International immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 167 citations in OpenAlex.

  1. Trial
  2. Article
  3. Single-Cell RNA Sequencing Reveals Granzyme KJournal of the American Heart Association · 2025
    Article
  4. Article
  5. Review
  6. Targeting Unc5b in macrophages drives atherosclerosis regression and pro-resolving immune cell function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  14. Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence.International journal of molecular sciences · 2023
    Review
  15. Pro-Healing Nanomatrix-Coated Stent Analysis in anACS applied materials & interfaces · 2022
    Article
  16. Targeting Immune Senescence in Atherosclerosis.International journal of molecular sciences · 2022
    Review
  17. Article
  18. MicroRNA profile of circulating CD4BMC cardiovascular disorders · 2022
    Article
  19. Review
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kevin TseDepartment of Internal Medicine, Division of Rheumatology, Allergy and Immunology, University of California at San Diego Medical Center, La Jolla, CA 92093, USA.
Harley Tse
John Sidney
Alex Sette
Klaus Ley
La Jolla Institute for Immunology · USDetroit R&D (United States) · USDiscovery Institute · USUniversity of California San Diego Medical Center · US

Funding

TRAINING IN MOLECULAR &CELL BIOLOGY OF ALLERGYT32AI007469 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 1994 to 2024
$6.9M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
NHLBI NIH HHS R01 HL115232NIAID NIH HHS T32 AI07469
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease of the artery wall. Atherosclerotic lesions contain monocytes, macrophages, smooth muscle cells and T lymphocytes. Here, we review the role of T-lymphocyte subsets in atherosclerosis. Among CD4⁺T cells, T(h)1 cells are pro-atherogenic, T(reg) cells are athero-protective and the role of T(h)2 and T(h)17 cells remains unclear. The role of follicular helper T cells in atherosclerosis remains unknown, as is the role of CD8⁺T cells. NKT cells bind glycolipid antigens and exert a pro-atherogenic role. The antigen specificity of T-cell responses in atherosclerosis is poorly understood. In order to enable antigen-specific prevention or therapy, a better understanding of these mechanisms is needed.

Indexed as

AnimalsAtherosclerosisHumansT-LymphocytesatherosclerosisinflammationT cell

Identifiers

PMID24154816
PMCPMC3806170
OpenAlexW2168987230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.