Evidence map›Paper›PMID 24154716›Full record

ReviewNature reviews. Cancer2013

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.

Eran Elinav, Roni Nowarski, Christoph A Thaiss, Bo Hu, Chengcheng Jin, Richard A Flavell

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06847529 (Systemic Inflammatory Markers As a Prognostic Index for B-cell Neoplasm , Single Center Experience .), which is not on this map. Cited by 1,183 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,183citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06847529 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Systemic Inflammatory Markers As a Prognostic Index for B-cell Neoplasm , Single Center Experience .

TypeobservationalSponsorAssiut UniversityRan2025 to 2025Enrolled70ConditionsB-cell Neoplasm
3 · Its place in the literature

Who cites it

1,183 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  11. The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  12. Article
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  15. Bidirectional Modulation of the Tumor Immune Microenvironment by Gut Microbiota-Derived Indoles: Mechanisms and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  16. Article
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1,123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eran Elinav1] Department of Immunology, Weizmann Institute of Science, 100 Herzl Street, Rehovot 76100, Israel. [2].
Roni Nowarski
Christoph A Thaiss
Bo Hu
Chengcheng Jin
Richard A Flavell

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Howard Hughes Medical Institute
6 · The paper itself

Abstract

Inflammation is a fundamental innate immune response to perturbed tissue homeostasis. Chronic inflammatory processes affect all stages of tumour development as well as therapy. In this Review, we outline the principal cellular and molecular pathways that coordinate the tumour-promoting and tumour-antagonizing effects of inflammation and we discuss the crosstalk between cancer development and inflammatory processes. In addition, we discuss the recently suggested role of commensal microorganisms in inflammation-induced cancer and we propose that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCarcinogenesisCell ProliferationCell Transformation, NeoplasticGenomeHomeostasisHumansImmunity, InnateInflammationMiceMicrobiotaNeoplasm MetastasisNeoplasmsSignal Transduction

Identifiers

PMID24154716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.