ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
The virulence of Streptococcus mutans and the ability to form biofilms.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
299 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Key virulence genes associated withFrontiers in oral health · 2025Pooled it
- Evaluation of residual carious dentin detection methods after cavity preparation: a randomized clinical trial.BMC oral health · 2024Trial
- Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.Molecular oral microbiology · 2026Review
- Resveratrol-loaded human dental pulp stem cell-derived exosomes enhance the efficacy of blue LED-mediated antimicrobial photodynamic therapy against mature cariogenic biofilms.Lasers in medical science · 2026Article
- Synergistic Antimicrobial and Antibiofilm Activity Optimization of aMicroorganisms · 2026Article
- Metal Alloys Used in Dental Prosthetics and Their Impact on the Oral Microbiome: Narrative Review.Dentistry journal · 2026Review
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Probiotic Bifidobacterium animalis subsp. lactis BL-11 attenuates dental caries development in a Streptococcus mutans-induced rat model.Odontology · 2026Article
- Patchouli Alcohol as a Potential Anti-Cariogenic Compound TargetingMolecules (Basel, Switzerland) · 2026Article
- Air restriction enhancesMicrobiology spectrum · 2026Article
- Adhesion index integrates cell and bacterial responses to titanium across protein conditioning and surface roughness.Biofilm · 2026Article
- Cranberry Polyphenol Extract (CPE) Oral Rinse Improves Salivary Microbiome in 6-n-Propylthiouracil (PROP) Non-Tasters and Palatability of Aronia Juice.International journal of molecular sciences · 2026Article
- Development and Ex Vivo Evaluation of a Thermoreversible Silver Nanoparticle-Loaded Gel as a Biocompatible Intracanal Medicament.Journal of functional biomaterials · 2026Article
- Anti-Cariogenic Effect of Trans-Cinnamaldehyde in an In Vitro Mouse Jaw Explant Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Antibacterial activity of a bioactive composite resins containing surface pre-reacted glass in a complex multispecies subgingival biofilm.Odontology · 2026Article
- The Penetration Depth and Bactericidal Efficacy of 2% Chlorhexidine Iontophoresis in Human Coronal Dentin In Vitro.International dental journal · 2026Article
- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- Evaluation of the Inactivation of Microorganisms by a Blue Laser (445 nm)-An In Vitro Study.Antibiotics (Basel, Switzerland) · 2026Article
- Impact of Modified Lactoperoxidase Systems on Glycolytic Metabolism and Virulence Factors inInternational journal of molecular sciences · 2026Article
- Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans.International journal of oral science · 2026Article
239 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In some diseases, a very important role is played by the ability of bacteria to form multi-dimensional complex structure known as biofilm. The most common disease of the oral cavity, known as dental caries, is a top leader. Streptococcus mutans, one of the many etiological factors of dental caries, is a microorganism which is able to acquire new properties allowing for the expression of pathogenicity determinants determining its virulence in specific environmental conditions. Through the mechanism of adhesion to a solid surface, S. mutans is capable of colonizing the oral cavity and also of forming bacterial biofilm. Additional properties enabling S. mutans to colonize the oral cavity include the ability to survive in an acidic environment and specific interaction with other microorganisms colonizing this ecosystem. This review is an attempt to establish which characteristics associated with biofilm formation--virulence determinants of S. mutans--are responsible for the development of dental caries. In order to extend the knowledge of the nature of Streptococcus infections, an attempt to face the following problems will be made: Biofilm formation as a complex process of protein-bacterium interaction. To what extent do microorganisms of the cariogenic flora exemplified by S. mutans differ in virulence determinants "expression" from microorganisms of physiological flora? How does the environment of the oral cavity and its microorganisms affect the biofilm formation of dominant species? How do selected inhibitors affect the biofilm formation of cariogenic microorganisms?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.