Evidence map›Paper›PMID 24154642›Full record

ArticleThe journal of nutrition, health & aging2013

Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group.

E Kelaiditi, M Cesari, M Canevelli, G Abellan van Kan, P-J Ousset, S Gillette-Guyonnet, P Ritz, F Duveau, M E Soto, V Provencher and 9 more

5 registry-linked trialsOpen access · bronzeAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 572 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
572citing papers in PubMed, 20 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428062 phase2 / phase3suspendednot on this mapstarted 2014, after this paper: background citation

Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial

TypeinterventionalSponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoRan2014 to 2019Enrolled1,812ConditionsPost-operative Cognitive DysfunctionArmsHemodynamic target, Phenylephrine, Intravenous fluids, Patient's positioning, Reduction of depth of anesthesia
NCT03824106 narecruitingnot on this mapstarted 2022, after this paper: background citation

Frailty Rehabilitation: A Community-based Intervention to Promote Healthy Aging

TypeinterventionalSponsorMcMaster UniversityRan2022 to 2025Enrolled324ConditionsFrailtyArmsControl, Group Exercise, Nutrition and Medication review, Protein Supplement, Vitamin D
NCT04467216 nacompletednot on this mapstarted 2020, after this paper: background citation

Virtual Reality Motor-cognitive Training for Older People With Cognitive Frailty: A Pilot Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2020 to 2020Enrolled17ConditionsCognitive FrailtyArmsComputerised cognitive training using virtual reality
NCT04730817 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Virtual Reality Motor-cognitive Training for Older People With Cognitive Frailty: The Implementation of the Prototype

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2021 to 2022Enrolled400ConditionsCognitive Frailty, Physical FunctionArmsVirtual Reality Motor-Cognitive Training System
NCT06797440 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Dual Tasks of Digital Technology on Cognitive Function and Physical Activity in the Older Adults With Cognitive Frailty - A Randomized Controlled Trial

TypeinterventionalSponsorNational Taipei University of Nursing and Health SciencesRan2025 to 2026Enrolled100ConditionsCognitive FrailtyArmsDual tasks of digital technology
3 · Its place in the literature

Who cites it

572 citing papers in PubMed, 20 syntheses or guidelines pooled it, 1,019 citations in OpenAlex.

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  2. Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026
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512 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

E KelaiditiEirini Kelaiditi, Institut du Vieillissement, Gérontopôle, Université de Toulouse III-Paul Sabatier. 37 Allées Jules Guesde, 31000 Toulouse, France. Phone: +33 (0) 56114-5668; Email: kelaiditi.e@chu-toulouse.fr.
M Cesari
M Canevelli
G Abellan van Kan
P-J Ousset
S Gillette-Guyonnet
P Ritz
F Duveau
M E Soto
V Provencher
F Nourhashemi
A Salvà
P Robert
S Andrieu
Y Rolland
J Touchon
J L Fitten
B Vellas
IANA/IAGG
Centre Hospitalier Universitaire de Toulouse · FRInserm · FRUniversité Toulouse III - Paul Sabatier · FRCentre Hospitalier Universitaire de Montpellier · FRCentre hospitalier universitaire de Québec · CAHôpital Rangueil · FRSapienza University of Rome · ITUniversitat Autònoma de Barcelona · ESUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons. In parallel, dementia and cognitive disorders also represent major healthcare and social priorities. Although physical frailty and cognitive impairment have shown to be related in epidemiological studies, their pathophysiological mechanisms have been usually studied separately. An International Consensus Group on "Cognitive Frailty" was organized by the International Academy on Nutrition and Aging (I.A.N.A) and the International Association of Gerontology and Geriatrics (I.A.G.G) on April 16th, 2013 in Toulouse (France). The present report describes the results of the Consensus Group and provides the first definition of a "Cognitive Frailty" condition in older adults. Specific aim of this approach was to facilitate the design of future personalized preventive interventions in older persons. Finally, the Group discussed the use of multidomain interventions focused on the physical, nutritional, cognitive and psychological domains for improving the well-being and quality of life in the elderly. The consensus panel proposed the identification of the so-called "cognitive frailty" as an heterogeneous clinical manifestation characterized by the simultaneous presence of both physical frailty and cognitive impairment. In particular, the key factors defining such a condition include: 1) presence of physical frailty and cognitive impairment (CDR=0.5); and 2) exclusion of concurrent AD dementia or other dementias. Under different circumstances, cognitive frailty may represent a precursor of neurodegenerative processes. A potential for reversibility may also characterize this entity. A psychological component of the condition is evident and concurs at increasing the vulnerability of the individual to stressors.

Indexed as

CognitionCognition DisordersConsensusPersons with DisabilitiesAgedAged, 80 and overAgingAlzheimer DiseaseDementiaFrail ElderlyGeriatric AssessmentGeriatricsHumansRisk FactorsSyndrome

Identifiers

PMID24154642
PMCPMC12878905
OpenAlexW2054664500

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.