ArticleOpen biology2013
A novel taxonomic marker that discriminates between morphologically complex actinomycetes.
Article in Open biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Complex multicellularity is linked with expanded specialized metabolite production in microorganisms.Nature microbiology · 2026Article
- Taxonomic description ofMicrobiology spectrum · 2025Article
- Biocontrol of Mycotoxigenic Fungi by Actinobacteria.Journal of fungi (Basel, Switzerland) · 2024Review
- TheJournal of bacteriology · 2024Article
- Genotype-phenotype correlations within theFrontiers in microbiology · 2022Article
- Diversity and Taxonomic Distribution of Endophytic Bacterial Community in the Rice Plant and Its Prospective.International journal of molecular sciences · 2021Review
- Marine Actinomycetes, New Sources of Biotechnological Products.Marine drugs · 2021Review
- An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG.mBio · 2021Article
- Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB inOpen biology · 2021Article
- Adaptation to Endophytic Lifestyle Through Genome Reduction byFrontiers in bioengineering and biotechnology · 2021Article
- Differential transcription of expanded gene families in central carbon metabolism ofAccess microbiology · 2020Article
- Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes.Nature communications · 2018Article
- High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.Journal of bacteriology · 2018Article
- Isolation of β-1,3-Glucanase-Producing Microorganisms fromMolecules (Basel, Switzerland) · 2018Article
- Streptomyces Differentiation in Liquid Cultures as a Trigger of Secondary Metabolism.Antibiotics (Basel, Switzerland) · 2018Review
- Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.Scientific reports · 2018Article
- Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity.Antonie van Leeuwenhoek · 2018Article
- Article
- SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures.Antonie van Leeuwenhoek · 2018Article
- Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the era when large whole genome bacterial datasets are generated routinely, rapid and accurate molecular systematics is becoming increasingly important. However, 16S ribosomal RNA sequencing does not always offer sufficient resolution to discriminate between closely related genera. The SsgA-like proteins are developmental regulatory proteins in sporulating actinomycetes, whereby SsgB actively recruits FtsZ during sporulation-specific cell division. Here, we present a novel method to classify actinomycetes, based on the extraordinary way the SsgA and SsgB proteins are conserved. The almost complete conservation of the SsgB amino acid (aa) sequence between members of the same genus and its high divergence between even closely related genera provides high-quality data for the classification of morphologically complex actinomycetes. Our analysis validates Kitasatospora as a sister genus to Streptomyces in the family Streptomycetaceae and suggests that Micromonospora, Salinispora and Verrucosispora may represent different clades of the same genus. It is also apparent that the aa sequence of SsgA is an accurate determinant for the ability of streptomycetes to produce submerged spores, dividing the phylogenetic tree of streptomycetes into liquid-culture sporulation and no liquid-culture sporulation branches. A new phylogenetic tree of industrially relevant actinomycetes is presented and compared with that based on 16S rRNA sequences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.