ArticleDiagnostic pathology2013
Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review of anticancer effects of radix astragali.Chinese journal of integrative medicine · 2016Pooled it
- Review on active components and mechanism of natural product polysaccharides against gastric carcinoma.Heliyon · 2024Review
- Evaluation of theInternational journal of molecular sciences · 2022Article
- Mechanism of Herb PairsEvidence-based complementary and alternative medicine : eCAM · 2022Article
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- Retraction Note: RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells.Diagnostic pathology · 2019Article
- Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system.Cancer management and research · 2019Article
- miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC.Oncology letters · 2018Article
- Recent Advances in Herbal Medicines for Digestive System Malignancies.Frontiers in pharmacology · 2018Review
- Anti-Aging Implications ofAging and disease · 2017Review
- Article
- Retraction Note: Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.Diagnostic pathology · 2017Article
- Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression.World journal of gastroenterology · 2017Article
- An elderly patient with advanced lung cancer achieved long-term survival using Chinese medicine: An alternative treatment strategy for cancer patients aged 80 or older without a tissue confirmed diagnosis.Chinese journal of integrative medicine · 2016Article
- An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract.Oncology reports · 2016Article
- High expression of DEK predicts poor prognosis of gastric adenocarcinoma.Diagnostic pathology · 2014Article
- Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer.Diagnostic pathology · 2014Article
- Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.International journal of clinical and experimental pathology · 2014Article
- The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.Diagnostic pathology · 2013Article
Corrections and comments
- Retraction · 2017-09-07Plagiarism of Text ·
- Retracted
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAstragalus memebranaceus is a traditional Chinese herbal medicine used in treatment of common cold, diarrhea, fatigue, anorexia and cardiac diseases. Recently, there are growing evidences that Astragalus extract may be a potential anti-tumorigenic agent. Some research showed that the total saponins obtained from Astragalus membranaceus possess significant antitumorigenic activity. Gastric cancer is one of the most frequent cancers in the world, almost two-thirds of gastric cancer cases and deaths occur in less developed regions. But the effect of Astragalus membranaceus on proliferation, invasion and apoptosis of gastric cancer BGC-823 cells remains unclear.
methodsAstragalus saponins were extracted. Cells proliferation was determined by CCK-8 assay. Cell cycle and apoptosis were detected by the flow cytometry. Boyden chamber was used to evaluate the invasion and metastasis capabilities of BGC-823 cells. Tumor growth was assessed by subcutaneous inoculation of cells into BALB/c nude mice.
resultsThe results demonstrated that total Astragalus saponins could inhibit human gastric cancer cell growth both in vitro and in vivo, in additional, Astragalus saponins deceased the invasion ability and induced the apoptosis of gastric cancer BGC-823 cells.
conclusionsTotal Astragalus saponins inhibited human gastric cancer cell growth, decreased the invasion ability and induced the apoptosis. This suggested the possibility of further developing Astragalus as an alternative treatment option, or perhaps using it as adjuvant chemotherapeutic agent in gastric cancer therapy.
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