ArticleThe ISME journal2014
Quantitative and qualitative impact of hospital effluent on dissemination of the integron pool.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hospital Wastewater as a Reservoir for Antibiotic Resistance Genes: A Meta-Analysis.Frontiers in public health · 2020Pooled it
- Optimized Organic Fertilization Mitigates Antibiotic Resistance Gene Dissemination in Manure-Amended Soils: A Field Study on Nutrient-Microbiome-Antibiotic Resistance Gene Nexus During Cabbage Reproductive Cycle.Antibiotics (Basel, Switzerland) · 2026Article
- Metagenomic profiling of microbial communities and the resistome within Egyptian hospital wastewater and tap water.Scientific reports · 2026Article
- Article
- Distinct ARG profiles associated with class 1 integrons in municipal and industrial wastewater treatment plants.Environmental science and ecotechnology · 2025Article
- The Impact of Wastewater on Antimicrobial Resistance: A Scoping Review of Transmission Pathways and Contributing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review.Microorganisms · 2024Review
- RISMEAU dataset: Pharmaceuticals and biocides concentrations in urban and agricultural sludge, amended soil and leachate and their environmental impacts.Data in brief · 2024Article
- Antibiotic resistance ofJournal of water and health · 2024Article
- Article
- Monitoring indicator genes to assess antimicrobial resistance contamination in phytoplankton and zooplankton communities from the English Channel and the North Sea.Frontiers in microbiology · 2024Article
- Article
- Distribution and antibiogram ofThe Pan African medical journal · 2023Article
- The fate of sulfonamide resistance genes and anthropogenic pollution markerFrontiers in microbiology · 2023Article
- Bacterial Resistance to β-Lactam Antibiotics in Municipal Wastewater: Insights from a Full-Scale Treatment Plant in Poland.Microorganisms · 2022Article
- Sources and Drivers of ARGs in Urban Streams in Atlanta, Georgia, USA.Microorganisms · 2022Article
- Cascade Filtration With PCR Detection and Field-Flow-Fractionation Online With ICP-MS for the Characterization of DNA Interaction With Suspended Particulate Matter.Frontiers in chemistry · 2022Article
- River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.Frontiers in microbiology · 2022Article
- Biochar and Manure Applications Differentially Altered the Class 1 Integrons, Antimicrobial Resistance, and Gene Cassettes Diversity in Paddy Soils.Frontiers in microbiology · 2022Article
- Dynamics of integron structures across a wastewater network - Implications to resistance gene transfer.Water research · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that human activity, and especially the resulting effluent, has a major role in the dissemination of bacterial antibiotic-resistance determinants in the environment. Hospitals are the major antibiotic consumers and thus facilitate the spread of antibiotic resistance. Questions are increasingly being raised about the management of hospital effluents, but their involvement in antibiotic-resistance dissemination has never been assessed. Integrons are a paradigm of genetic transfer between the environmental resistome and both commensal and pathogenic bacteria. In order to assess the impact of hospital activities on antibiotic-resistance dissemination in the environment, we monitored integrons and their gene cassettes in hospital effluents, and their release in the environment. We found that bacterial communities present in a hospital effluent contained a high proportion of integrons. In terms of both their gene cassette diversity and gene cassette arrays, the urban effluent and municipal wastewater treatment plant (WWTP) influent were most similar, whereas the hospital effluent and recirculation sludge exhibited very specific patterns. We found that anthropogenic activities led to the release of abundant integrons and antibiotic-resistance gene cassettes, but we observed no specific impact of hospital activities on the receiving environment. Furthermore, although the WWTP did not reduce the normalized integron copy number, it reduced the diversity of gene cassette arrays contained in the raw wastewater, underlining the effect of the biological treatment on the anthropogenic integron pool arriving at the WWTP.
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