ArticleRNA (New York, N.Y.)2013
Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains.
Article in RNA (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders.Neurobiology of aging · 2023Article
- Statistical inference of differential RNA-editing sites from RNA-sequencing data by hierarchical modeling.Bioinformatics (Oxford, England) · 2020Article
- Article
- A-to-I RNA editing - immune protector and transcriptome diversifier.Nature reviews. Genetics · 2018Review
- Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques.RNA (New York, N.Y.) · 2018Article
- Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins.Frontiers in molecular neuroscience · 2018Article
- Review
- Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition.Scientific reports · 2017Article
- Identification of human RNA editing sites: A historical perspective.Methods (San Diego, Calif.) · 2016Review
- Dynamic regulation of RNA editing in human brain development and disease.Nature neuroscience · 2016Article
- From sauropsids to mammals and back: New approaches to comparative cortical development.The Journal of comparative neurology · 2016Review
- Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease.RNA (New York, N.Y.) · 2016Article
- The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3.G3 (Bethesda, Md.) · 2015Article
- Regulatory factors governing adenosine-to-inosine (A-to-I) RNA editing.Bioscience reports · 2015Review
- Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony.Current opinion in genetics & development · 2014Review
- Evolutionary dynamics of coding and non-coding transcriptomes.Nature reviews. Genetics · 2014Review
- Analytical tools and current challenges in the modern era of neuroepigenomics.Nature neuroscience · 2014Review
- Conserved microRNA editing in mammalian evolution, development and disease.Genome biology · 2014Article
- Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?Frontiers in cellular and infection microbiology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play important roles in neuronal functions. In this study we investigated RNA-editing changes during human brain development and maturation, as well as evolutionary conservation of RNA-editing patterns across primates. We used high-throughput transcriptome sequencing (RNA-seq) to quantify the RNA-editing levels and assess ontogenetic dynamics of RNA editing at more than 8000 previously annotated exonic A-to-I RNA-editing sites in two brain regions--prefrontal cortex and cerebellum--of humans, chimpanzees, and rhesus macaques. We observed substantial conservation of RNA-editing levels between the brain regions, as well as among the three primate species. Evolutionary changes in RNA editing were nonetheless evident, with 40% of the annotated editing sites studied showing divergent editing levels among the three species and 16.5% of sites displaying statistically significant human-specific editing patterns. Across lifespan, we observed an increase of the RNA-editing level with advanced age in both brain regions of all three primate species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.