ArticleInternational journal of molecular sciences2013
The effect on proliferation and differentiation of cementoblast by using sclerostin as inhibitor.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- SphK1/mitophagy axis in cementocytes drives orthodontic root resorption via mitochondrial transfer to osteoclasts.Bone research · 2026Article
- In silico identification of sclerostin inhibitors.Molecular diversity · 2026Article
- Ferroptosis-driven cell death perpetuates the chronic inflammatory cycle in periodontitis: a single-cell transcriptomic study.Frontiers in cell and developmental biology · 2026Article
- Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis.Journal of dental sciences · 2024Article
- Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study.Biological procedures online · 2023Article
- Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry.Journal of translational medicine · 2022Review
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Extracellular Vesicles Derived From Murine Cementoblasts Possess the Potential to Increase Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis.Frontiers in physiology · 2022Article
- Xingfu Bao et al. The Effect on Proliferation and Differentiation of Cementoblast by Using Sclerostin as Inhibitor.International journal of molecular sciences · 2019Article
- [Effect of sclerostin on the functions and related mechanisms of cementoblasts under mechanical stress].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- The role of sclerostin and dickkopf-1 in oral tissues - A review from the perspective of the dental disciplines.F1000Research · 2019Review
- Article
- Interleukin-1β induces human cementoblasts to support osteoclastogenesis.International journal of oral science · 2017Article
- Tetrahydroxystilbene glucoside isolated fromExperimental and therapeutic medicine · 2017Article
- SOST silencing promotes proliferation and invasion and reduces apoptosis of retinoblastoma cells by activating Wnt/β-catenin signaling pathway.Gene therapy · 2017Article
- Review
- [Preliminary research on the expression of sclerostin mediated by bone morphogenetic protein 2 in cementoblast].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Article
- Strontium promotes cementoblasts differentiation through inhibiting sclerostin expression in vitro.BioMed research international · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cementogenesis is of great importance for normal teeth root development and is involved in the repair process of root resorption caused by orthodontic treatment. As highly differentiated mesenchymal cells, cementoblasts are responsible for this process under the regulation of many endogenous agents. Among these molecules, sclerostin has been much investigated recently for its distinct antagonism effect on bone metabolism. Encoded by the sost gene, sclerostin is expressed in osteocytes and cementocytes of cellular cementum. it is still unclear. In the current study, we investigated the effects of sclerostin on the processes of proliferation and differentiation; a series of experiments including MTT, apoptosis examination, alkaline phosphatase (ALP) activity, gene analysis, and alizarin red staining were carried out to evaluate the proliferation and differentiation of cementoblasts. Protein expression including osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) were also checked to analyze changes in osteoclastogenesis. Results show that sclerostin inhibits cementoblasts proliferation and differentiation, and promotes osteoclastogenesis. Interestingly, the monoclonal antibody for sclerostin has shown positive effects on osteoporosis, indicating that it may facilitate cementogenesis and benefit the treatment of cementum related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.