ArticleCardiovascular diabetology2013
Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease.International journal of molecular sciences · 2023Review
- Article
- Is Obesity a Risk Factor for Carotid Atherosclerotic Disease?-Opportunistic Review.Journal of cardiovascular development and disease · 2022Review
- Association of Carotid Intima Media Thickness With Metabolic Syndrome Among Low-Income Middle-Aged and Elderly Chinese: A Population-Based Cross-Sectional Study.Frontiers in cardiovascular medicine · 2021Article
- Predicting Progression of COVID-19 Infection to Prioritize Medical Resource Allocation: A Novel Triage Model Based on Patient Characteristics and Symptoms at Presentation.Frontiers in public health · 2021Article
- Evaluation of carotid atherosclerosis and related risk factors using ultrasonic B-Flow technology in elderly patients.The Journal of international medical research · 2020Article
- Analysis of risk factors for carotid intima-media thickness in patients with type 2 diabetes mellitus in Western China assessed by logistic regression combined with a decision tree model.Diabetology & metabolic syndrome · 2020Article
- Clinical Utility of Carotid Ultrasonography in the Prediction of Cardiovascular Events in Patients with Diabetes: A Combined Analysis of Data Obtained in Five Longitudinal Studies.Journal of atherosclerosis and thrombosis · 2018Article
- High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population.European radiology · 2016Article
- The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes.Cardiovascular diabetology · 2016Article
- Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry.Cardiovascular diabetology · 2015Observational
- Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study.Cardiovascular diabetology · 2015Observational
- Association between metabolic syndrome and multiple lesions of intracranial atherothrombotic stroke: a hospital-based study.Cardiovascular diabetology · 2015Article
- Treatment-dependent and treatment-independent risk factors associated with the risk of diabetes-related events: a retrospective analysis based on 229,042 patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2015Article
- Effectiveness of sulphonylureas in the therapy of diabetes mellitus type 2 patients: an observational cohort study.Journal of diabetes and metabolic disorders · 2015Article
- Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor.Cardiovascular diabetology · 2014Review
- Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients.Cardiovascular diabetology · 2014Article
- Subclinical vascular inflammation in subjects with normal weight obesity and its association with body fat: an 18 F-FDG-PET/CT study.Cardiovascular diabetology · 2014Article
- Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study.Cardiovascular diabetology · 2014Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundIntima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events. PATIENTS: We studied a population of 529 asymptomatic patients (age 62 ± 12.8 years), divided into two groups of subjects with and without Metabolic Syndrome (MetS).
methodsAll patients, at baseline, have had a carotid ultrasound evaluation and classified in two subgroups: the first one without atherosclerotic lesions and the second one with preclinical atherosclerosis (increased IMT or asymptomatic carotid plaque). Cardiovascular endpoints were investigated in a 20-years follow-up.
resultsThere were 242 cardiovascular events: 144 among patients with MetS and 98 among in healthy controls (57.4% vs. 35.2%; P < 0.0001). 63 events occurred in patients with normal carotid arteries, while 179 events occurred in patients with preclinical atherosclerosis (31.8% vs. 54.1%; P < 0.0001). Of the 144 total events occurred in patients with MetS, 36 happened in the subgroup with normal carotid arteries and 108 in the subgroup with preclinical atherosclerosis (45% vs. 63.15%; P = 0.009). 98 events occurred in patients without MetS, of which 27 in the subgroup with normal carotid arteries and 71 in the subgroup with preclinical atherosclerosis (22.88% vs. 44.37%; P = 0.0003). In addition, considering the 63 total events occurred in patients without atherosclerotic lesions, 36 events were recorded in the subgroup with MetS and 27 events in the subgroup without MetS (45% vs. 22.88%; P = 0.0019). Finally, in 179 total events recorded in patients with preclinical carotid atherosclerosis, 108 happened in the subgroup with MetS and 71 happened in the subgroup without MetS (63.15% vs. 44.37%; P = 0.0009). The Kaplan-Meier function showed an improved survival in patients without atherosclerotic lesions compared with patients with carotid ultrasound alterations (P = 0.01, HR: 0.7366, CI: 0.5479 to 0.9904).
conclusionsPreclinical atherosclerosis leads to an increased risk of cardiovascular events, especially if it is associated with MetS.
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