ArticleBioMed research international2013
An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Oxidative Stress Profile of Mothers and Their Offspring after Maternal Consumption of High-Fat Diet in Rodents: A Systematic Review and Meta-Analysis.Oxidative medicine and cellular longevity · 2021Pooled it
- Systems Pharmacology and Multitarget Modulation of Letrozole-HFD-Induced Polycystic Ovarian Syndrome by Fruit Pulp of Prunus armeniaca.Chemistry & biodiversity · 2026Article
- Circulating Family with Sequence Similarity 19, Member A5 as a Potential Indicator of Atherogenic Risk: Correlations with Low-Density Lipoprotein/Apolipoprotein B Ratio, Atherogenic Index, and Castelli Indices in Diet-Induced Obesity.Iranian journal of medical sciences · 2026Article
- Effects of Psyllium Husk on Metabolic Regulators, Insulin Resistance, and SIRT6 in Liver and Muscle of Type 2 Diabetic Rats.Veterinary medicine and science · 2026Article
- Crude Extract and Phenol-Rich Fractions fromJournal of xenobiotics · 2026Article
- Impact of Varied Dietary Macronutrient Ratios on the Nutrition Status of Swiss Albino Mice.Food science & nutrition · 2025Article
- Protective effects of aerobic exercise on cardiac histology and stereological parameters in a rat model of type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2025Article
- Effect of Nutrition on Drug-Induced Liver Injury: Insights from a High-Fat Diet Mouse Model.Turkish journal of pharmaceutical sciences · 2024Article
- The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress.International journal of molecular sciences · 2024Article
- Sex-specific effects of a high fat diet on aortic inflammation and dysfunction.Scientific reports · 2023Article
- Comparison of the Nutritional Status of Swiss Albino Mice Fed on Either a Purified or Cereal-Based Diet for 15 weeks.Biochemistry research international · 2023Article
- Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats.Scientific reports · 2022Article
- Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies.IBRO neuroscience reports · 2022Article
- Anti-PCSK9 monoclonal antibody attenuates high-fat diet and zymosan-induced vascular inflammation in C57BL/6 mice by modulating TLR2/NF-ƙB signaling pathway.Iranian journal of basic medical sciences · 2022Article
- Modulatory role of atorvastatin against high-fat diet and zymosan-induced activation of TLR2/NF-ƙB signaling pathway in C57BL/6 mice.Iranian journal of basic medical sciences · 2021Article
- Garcinia mangostana extract and curcumin ameliorate oxidative stress, dyslipidemia, and hyperglycemia in high fat diet-induced obese Wistar albino rats.Scientific reports · 2021Article
- Estrogen-dependent hypersensitivity to diabetes-evoked cardiac autonomic dysregulation: Role of hypothalamic neuroinflammation.Life sciences · 2020Article
- Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.Journal of cardiovascular pharmacology · 2020Article
- Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice.Scientific reports · 2019Article
- Estrogen-Dependent Disruption of Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats.The Journal of pharmacology and experimental therapeutics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research studies on diet-induced metabolic disorders in albino rats. Male Wistar rats were fed with normal pellet diet (NPD) or customized NCDs I, II, III or HFDs I, II, III for 12 weeks and parameters, namely, body weight, visceral adiposity, serum triglycerides, cholesterol, and glucose were evaluated to select an appropriate NCD and HFD. The selected HFD was further evaluated for induction of fatty liver, whilst type 2 diabetes (T2D) induction was confirmed in HFD and streptozotocin (STZ) induced diabetes model in Wistar rats. Amongst different diets tested, NCD-I and HFD-I were selected, since NCD-I exhibited close resemblance to NPD, whereas HFD-I induced metabolic alterations, particularly obesity and dyslipidemia consistently. Moreover, HFD-I elevated terminal hepatic lipids, while HFD-I/STZ treatment augmented insulin resistance index and serum glucose levels significantly indicating effective induction of fatty liver and T2D, respectively. Therefore, customized semipurified NCD-I and HFD-I can be recommended for research studies on diet-induced metabolic disorders in albino Wistar rats.
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