ArticleBioMed research international2013
Coating with autologous plasma improves biocompatibility of mesh grafts in vitro: development stage of a surgical innovation.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- PRP Therapy for Stress Urinary Incontinence and Pelvic Organ Prolapse: A New Frontier in Personalized Treatment?Journal of personalized medicine · 2025Review
- Platelet-Rich Therapies in Hernia Repair: A Comprehensive Review of the Impact of Platelet Concentrates on Mesh Integration in Hernia Management.Biomolecules · 2024Review
- Effect of the platelet-rich plasma covering of polypropylene mesh on oxidative stress, inflammation, and adhesions.International urogynecology journal · 2020Article
- Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions.Central European journal of urology · 2017Article
- The future of stem cell therapy in hernia and abdominal wall repair.Hernia : the journal of hernias and abdominal wall surgery · 2015Review
- Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation.BioMed research international · 2014Article
- Coating of mesh grafts for prolapse and urinary incontinence repair with autologous plasma: exploration stage of a surgical innovation.BioMed research international · 2014Article
- Can platelet-rich plasma coating improve polypropylene mesh integration? An immunohistochemical analysis in rabbits.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Effect of platelet-rich plasma on polypropylene meshes implanted in the rabbit vagina: histological analysis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Histological response to platelet-rich plasma added to polypropylene mesh implemented in rabbits.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate mesh coating modalities with autologous blood components in a recently developed in vitro test system for biocompatibility assessment of alloplastic materials. MATERIALS AND
methodsSeven different mesh types, currently used in various indications, were randomly investigated. Meshes were coated prior to cultivation with autologous peripheral blood mononuclear cells (PBMCs), platelets, and blood plasma. Pretreated meshes were incubated over 6 weeks in a minced tissue assay, representative for fibroblasts, muscle cells, and endothelial cells originating from 10 different patients. Adherence of those tissues on the meshes was microscopically investigated and semiquantitatively assessed using a previously described scoring system.
resultsCoating with peripheral blood mononuclear cells did not affect the adherence score, whereas coating with platelets and blood plasma increased the score suggesting improved biocompatibility in vitro. The previous ranking of native meshes remained consistent after coating.
conclusionPlasma coating of meshes improves their biocompatibility score in a novel in vitro test system.
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