ReviewAutism research and treatment2013
Neuropathology and animal models of autism: genetic and environmental factors.
Review in Autism research and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Behavioral phenotyping identifies autism-like repetitive stereotypies in a Tsc2 haploinsufficient rat model.Behavioral and brain functions : BBF · 2025Article
- Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes.Brain sciences · 2023Article
- Prenatal exposure to ambient air pollution and autism spectrum disorders: Results from a family-based case-control study.JCPP advances · 2023Article
- Near-infrared spectroscopy in child and adolescent neurodevelopmental disorders.PCN reports : psychiatry and clinical neurosciences · 2022Review
- NMR-Based Metabolomics of Rat Hippocampus, Serum, and Urine in Two Models of Autism.Molecular neurobiology · 2022Article
- Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration.Nutrients · 2022Article
- The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.Nutrients · 2021Review
- Sleep Disorders in Children With Autism Spectrum Disorder: Insights From Animal Models, Especially Non-human Primate Model.Frontiers in behavioral neuroscience · 2021Review
- Simultaneous Blockade of Histamine HBiomolecules · 2020Article
- The Dual-Active Histamine HInternational journal of molecular sciences · 2020Article
- Non-classical human leukocyte antigen class I in Tunisian children with autism.Central-European journal of immunology · 2020Article
- Review
- Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants.International journal of genomics · 2019Review
- Maternal SSRIs experience and risk of ASD in offspring: a review.Toxicology research · 2018Review
- FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children.BMC psychiatry · 2018Article
- Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder.Metabolic brain disease · 2018Article
- Investigating the effects of environmental factors on autism spectrum disorder in the USA using remotely sensed data.Environmental science and pollution research international · 2018Article
- Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder.Frontiers in neuroscience · 2018Review
- A Developmental Study of Abnormal Behaviors and Altered GABAergic Signaling in the VPA-Treated Rat Model of Autism.Frontiers in behavioral neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a heterogeneous behaviorally defined neurodevelopmental disorder. It is defined by the presence of marked social deficits, specific language abnormalities, and stereotyped repetitive patterns of behavior. Because of the variability in the behavioral phenotype of the disorder among patients, the term autism spectrum disorder has been established. In the first part of this review, we provide an overview of neuropathological findings from studies of autism postmortem brains and identify the cerebellum as one of the key brain regions that can play a role in the autism phenotype. We review research findings that indicate possible links between the environment and autism including the role of mercury and immune-related factors. Because both genes and environment can alter the structure of the developing brain in different ways, it is not surprising that there is heterogeneity in the behavioral and neuropathological phenotypes of autism spectrum disorders. Finally, we describe animal models of autism that occur following insertion of different autism-related genes and exposure to environmental factors, highlighting those models which exhibit both autism-like behavior and neuropathology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.