ReviewArchaea (Vancouver, B.C.)2013
Protein adaptations in archaeal extremophiles.
Review in Archaea (Vancouver, B.C.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
118 citing papers in PubMed.
- Metabolic adaptations of extremophiles and their applications in environmental biotechnology.World journal of microbiology & biotechnology · 2026Review
- Metals and Extremophilic Bacteria in Mining Environments: A Systematic Review.Microorganisms · 2026Review
- Microbial drivers of ammonium accumulation in Holocene sediments of the Pearl River Delta.Nature communications · 2026Article
- Highly diverse diazotrophs drive high NFundamental research · 2026Article
- Histone diversity in the archaeal domain of life.Nature communications · 2026Article
- Cross-domain transfer of trehalose biosynthesis genes contributes to adaptation in high-altitude environments.National science review · 2026Article
- Microbial Distributions Across Wide-Ranging Temperature Gradients of Hot Springs in Thailand: A Review of 35 Years of Research on Hot Spring-Associated Microorganisms.Environmental microbiology reports · 2026Review
- Diversity of Archaea.Progress in molecular and subcellular biology · 2026Review
- The Thermococcales as a model system: historical perspectives and emerging tools.Journal of bacteriology · 2025Review
- Intertwining of Cellular Osmotic Stress Handling Mechanisms and Heavy Metal Accumulation.Molecular biotechnology · 2025Review
- Cryo-EM study and in vivo chemical mapping of the Methanosarcina acetivorans ribosome and its dimerization via a repurposed enzyme and translation factor.The Journal of biological chemistry · 2025Article
- Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions.Nature microbiology · 2025Article
- Repeatability of protein structural evolution following convergent gene fusions.Nature communications · 2025Article
- Tat-dependent bundling pilus of a halophilic archaeon assembles by a strand donation mechanism and facilitates biofilm formation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A type IV pili-mediated mutualism between two co-resident temperate archaeal viruses and their host.Cell reports · 2025Article
- G-quadruplex structures in 16S rRNA regions correlate with thermal adaptation in prokaryotes.Nucleic acids research · 2025Article
- Structure-Function Relationship of the β-Hairpin ofInternational journal of molecular sciences · 2025Article
- Circular RNAs in Archaea.Advances in experimental medicine and biology · 2025Review
- Establishment of an efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate.Frontiers in microbiology · 2025Article
- HyperMPNN-A general strategy to design thermostable proteins learned from hyperthermophiles.bioRxiv : the preprint server for biology · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Extremophiles, especially those in Archaea, have a myriad of adaptations that keep their cellular proteins stable and active under the extreme conditions in which they live. Rather than having one basic set of adaptations that works for all environments, Archaea have evolved separate protein features that are customized for each environment. We categorized the Archaea into three general groups to describe what is known about their protein adaptations: thermophilic, psychrophilic, and halophilic. Thermophilic proteins tend to have a prominent hydrophobic core and increased electrostatic interactions to maintain activity at high temperatures. Psychrophilic proteins have a reduced hydrophobic core and a less charged protein surface to maintain flexibility and activity under cold temperatures. Halophilic proteins are characterized by increased negative surface charge due to increased acidic amino acid content and peptide insertions, which compensates for the extreme ionic conditions. While acidophiles, alkaliphiles, and piezophiles are their own class of Archaea, their protein adaptations toward pH and pressure are less discernible. By understanding the protein adaptations used by archaeal extremophiles, we hope to be able to engineer and utilize proteins for industrial, environmental, and biotechnological applications where function in extreme conditions is required for activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.