ArticleChemistry (Weinheim an der Bergstrasse, Germany)2013
Zwitterionic moieties from the Huisgen reaction: a case study with amphiphilic dendritic assemblies.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Design, Synthesis, and Characterization of Fully Zwitterionic, Functionalized Dendrimers.ACS omega · 2019Article
- Protein-triggered supramolecular disassembly: insights based on variations in ligand location in amphiphilic dendrons.Journal of the American Chemical Society · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Supramolecular nano-assemblies that reduce nonspecific interactions with biological macromolecules, such as proteins, are of great importance for various biological applications. Recently, zwitterionic materials have been shown to reduce nonspecific interactions with biomolecules, owing both to their charge neutrality and their ability to form a strong hydration layer around zwitterions via electrostatic interactions. Here, new triazole-based zwitterionic moieties are presented that are incorporated as the hydrophilic functionalities in facially amphiphilic dendrons. The amphiphilic zwitterionic dendrons spontaneously self-assemble in aqueous solutions forming micelle-type aggregates, which were confirmed by DLS, TEM, and fluorescence techniques. The structural and functional characteristics of the zwitterionic dendrons are also compared with the corresponding charge-neutral PEG-based dendrons and anionic carboxylate-based dendrons. Surface-charge measurements, temperature sensitivity and evaluation of interactions of these assemblies with proteins form the bases for these comparisons.
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Registered trials
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