ArticleProteins2014
CASP10 results compared to those of previous CASP experiments.
Article in Proteins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
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- Enhanced GROMACS: toward a better numerical simulation framework.Journal of molecular modeling · 2019Article
- Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors.International journal of molecular sciences · 2019Review
- A Comparative Study of Modern Homology Modeling Algorithms for Rhodopsin Structure Prediction.ACS omega · 2018Article
- HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information.Nucleic acids research · 2018Article
- Protein structure model refinement in CASP12 using short and long molecular dynamics simulations in implicit solvent.Proteins · 2018Article
- Evaluation of the template-based modeling in CASP12.Proteins · 2018Article
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- Impact of domain knowledge on blinded predictions of binding energies by alchemical free energy calculations.Journal of computer-aided molecular design · 2018Article
- Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case.Scientific reports · 2017Article
- Article
- New encouraging developments in contact prediction: Assessment of the CASP11 results.Proteins · 2016Article
- Template-based protein structure prediction in CASP11 and retrospect of I-TASSER in the last decade.Proteins · 2016Article
- Assessment of refinement of template-based models in CASP11.Proteins · 2016Article
- Critical assessment of methods of protein structure prediction: Progress and new directions in round XI.Proteins · 2016Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
We compare results of the community efforts in modeling protein structures in the tenth CASP experiment, with those in earlier CASPs particularly in CASP5, a decade ago. There is a substantial improvement in template based model accuracy as reflected in more successful modeling of regions of structure not easily derived from a single experimental structure template, most likely reflecting intensive work within the modeling community in developing methods that make use of multiple templates, as well as the increased number of experimental structures available. Deriving structural information not obvious from a template is the most demanding as well as one of the most useful tasks that modeling can perform. Thus this is gratifying progress. By contrast, overall backbone accuracy of models appears little changed in the last decade. This puzzling result is explained by two factors--increased database size in some ways makes it harder to choose the best available templates, and the increased intrinsic difficulty of CASP targets as experimental work has progressed to larger and more unusual structures. There is no detectable recent improvement in template-free modeling, but again, this may reflect the changing nature of CASP targets.
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