Evidence map›Paper›PMID 24150782›Full record

Trial reportEuropean journal of applied physiology2014

Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat.

Cecilia M Shing, Jonathan M Peake, Chin Leong Lim, David Briskey, Neil P Walsh, Matthew B Fortes, Kiran D K Ahuja, Luis Vitetta

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530929 (Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners), which is not on this map. Cited by 119 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 20 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530929 nacompletednot on this mapstarted 2018, after this paper: background citation

Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners

TypeinterventionalSponsorMedical University of BialystokRan2018 to 2018Enrolled66ConditionsGastrointestinal Disorder, FunctionalArmsSANPROBI BARRIER, PLACEBO
3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 20 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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  17. Impact of Probiotics on the Performance of Endurance Athletes: A Systematic Review.International journal of environmental research and public health · 2021
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Cecilia M ShingSport Performance Optimisation Research Team, School of Human Life Sciences, University of Tasmania, Locked Bag 1320, Launceston, TAS, 7250, Australia, Cecilia.Shing@utas.edu.au.
Jonathan M Peake
Chin Leong Lim
David Briskey
Neil P Walsh
Matthew B Fortes
Kiran D K Ahuja
Luis Vitetta
Bangor University · GBUniversity of Queensland · AUUniversity of Tasmania · AUNational University of Singapore · SGQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the effects of multi-strain probiotics supplementation on gastrointestinal permeability, systemic markers of inflammation and running performance when exercising in the heat.

methodsTen male runners were randomized to 4 weeks of daily supplementation with a probiotics capsule (45 billion CFU of Lactobacillus, Bifidobacterium and Streptococcus strains) or placebo, separated by a washout period (double-blind, cross-over trial). After each treatment, the runners exercised to fatigue at 80% of their ventilatory threshold at 35 °C and 40% humidity. To assess gastrointestinal permeability, runners ingested lactulose and rhamnose before exercise and post-exercise urine was collected to measure sugar concentrations. Venous blood samples were collected before, immediately after and 1 h after exercise, and core temperature was monitored during exercise.

resultsProbiotics supplementation significantly increased run time to fatigue (min:s 37:44 ± 2:42 versus 33:00 ± 2:27; P = 0.03, d = 0.54). Average core temperature during exercise was similar between trials (probiotic 38.1 ± 0.2 °C, placebo 38.1 ± 0.1 °C; P = 0.77, d = 0.13). Serum lipopolysaccharide concentration increased post-exercise (P < 0.001), while there was a moderate to large reduction in pre-exercise (d = 0.70) and post-exercise (d = 1.24) concentration following probiotics supplementation. Plasma concentrations of IL-6, IL-10 and IL-1ra increased after exercise (P < 0.01), but there was no significant difference between trials (P > 0.05). There was a small to moderate reduction (d = 0.35) in urine lactulose:rhamnose and a small reduction (d = 0.25) in symptoms of gastrointestinal discomfort following probiotics supplementation (both P = 0.25).

conclusionFour weeks of supplementation with a multi-strain probiotic increased running time to fatigue in the heat. Further studies are required to elucidate the exact mechanisms for this performance benefit.

Indexed as

Hot TemperatureRunningAdultCross-Over StudiesCytokinesDouble-Blind MethodExercise ToleranceGastrointestinal TractHumansInflammationIntestinal AbsorptionMaleProbioticsCytokines

Identifiers

PMID24150782
OpenAlexW1601403942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.