ReviewCurrent allergy and asthma reports2013
Primary mast cell disorders in children.
Review in Current allergy and asthma reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02761473 (Cutaneous Mastocytosis in Children), which is not on this map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations
Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Development and validation of a quality of life scale for pediatric mastocytosis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis.Clinical case reports · 2018Article
- Mastocytosis in Children.Current allergy and asthma reports · 2017Review
- The role of serum tryptase in the diagnosis and monitoring of pediatric mastocytosis: a single-center experience.Postepy dermatologii i alergologii · 2017Article
- Multiple red-brown macules and papules in a toddler.Paediatrics & child health · 2017Article
- Targeted Treatment Options in Mastocytosis.Frontiers in medicine · 2017Review
- Prevalence, pathogenesis, and treatment options for mastocytosis-related osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Transient hypogammaglobulinaemia of infants in children with mastocytosis - strengthened indications for vaccinations.Central-European journal of immunology · 2016Article
- KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis.Leukemia · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mastocytosis arises from clonal mast cell expansion and the resultant accumulation of mast cells in cutaneous and sometimes extracutaneous tissues. Recent studies have demonstrated that c-kit mutations seem to be more prevalent in pediatric mastocytosis than previously assumed, but what determines disease evolution and severity in the individual patient remains elusive. For the large majority of children, mastocytosis is a self-limited cutaneous disease that spontaneously regresses before they reach adult age. Rarely, children develop systemic disease progression that is the hallmark of adult-onset disease. Therefore, invasive diagnostic testing, including performing a bone marrow biopsy, is not routinely recommended and usually reserved for children that present with signs of systemic involvement and persistently elevated serum tryptase levels. Despite its often-transient nature and limited skin involvement, some children experience challenging disease-associated symptoms due to spontaneous or trigger-induced mast cell degranulation. Anticipation of and preparation for potential complications can in many instances avoid symptomatic exacerbations. Proper symptomatic treatment and supportive care can often improve the child's quality of life. Cytoreductive therapy is usually not indicated given the natural history of spontaneous disease resolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.