ArticleeLife2013
Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Wild barley cytoplasms reduce grain weight plasticity, with environment-dependent cytonuclear epistasis at theMolecular breeding : new strategies in plant improvement · 2026Article
- Levels of additive genetic variation vary substantially between species.PLoS biology · 2026Article
- The role of mitotype variation and positive epistasis in trait differences between Saccharomyces species.Genetics · 2026Article
- Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A trans-species cytoplasmic polymorphism is associated with seed shape and aridity across multiple species of sunflowers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hybridization and gene expression: Beyond differentially expressed genes.Molecular ecology · 2025Review
- OptimizingPlants (Basel, Switzerland) · 2024Review
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Salt tolerance QTLs of an endemic rice landrace, Horkuch at seedling and reproductive stages.Scientific reports · 2022Article
- Electroporation of Small Interfering RNAs into Tibialis Anterior Muscles of Mice.Bio-protocol · 2022Article
- Genome-wide association studies of five free amino acid levels in rice.Frontiers in plant science · 2022Article
- Genome-wide association study on metabolite accumulation in a wild barley NAM population reveals natural variation in sugar metabolism.PloS one · 2021Article
- The Consequences of a Disruption in Cyto-Nuclear Coadaptation on the Molecular Response to a Nitrate Starvation in Arabidopsis.Plants (Basel, Switzerland) · 2020Article
- Gene Duplication Accelerates the Pace of Protein Gain and Loss from Plant Organelles.Molecular biology and evolution · 2020Article
- Article
- Reciprocal cybrids reveal how organellar genomes affect plant phenotypes.Nature plants · 2020Article
- Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes inGenetics · 2019Article
- Daniel J. Kliebenstein.The Plant cell · 2018Article
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5 authors.
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Abstract
Understanding genome to phenotype linkages has been greatly enabled by genomic sequencing. However, most genome analysis is typically confined to the nuclear genome. We conducted a metabolomic QTL analysis on a reciprocal RIL population structured to examine how variation in the organelle genomes affects phenotypic variation. This showed that the cytoplasmic variation had effects similar to, if not larger than, the largest individual nuclear locus. Inclusion of cytoplasmic variation into the genetic model greatly increased the explained phenotypic variation. Cytoplasmic genetic variation was a central hub in the epistatic network controlling the plant metabolome. This epistatic influence manifested such that the cytoplasmic background could alter or hide pairwise epistasis between nuclear loci. Thus, cytoplasmic genetic variation plays a central role in controlling natural variation in metabolomic networks. This suggests that cytoplasmic genomes must be included in any future analysis of natural variation. DOI: http://dx.doi.org/10.7554/eLife.00776.001.
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