ArticleNeuroradiology2013
Measurement of choroid plexus perfusion using dynamic susceptibility MR imaging: capillary permeability and age-related changes.
Article in Neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Lifespan Modeling of Choroid Plexus Volume in Multiple Sclerosis and Its Dynamic Associations With Clinical, MRI, and HLA Susceptibility.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Age-related Vascular Alterations in the Choroid Plexus: Novel Insights from Pathophysiology and Imaging Studies.Aging and disease · 2025Review
- Review
- Region-informed machine learning model for choroid plexus segmentation in Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects.Fluids and barriers of the CNS · 2024Article
- Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems.Journal of Alzheimer's disease : JAD · 2024Review
- Choroid plexus imaging to track neuroinflammation - a translational model for mouse and human studies.Neural regeneration research · 2023Article
- The choroid plexus: a missing link in our understanding of brain development and function.Physiological reviews · 2023Review
- DCE-MRI of Brain Fluid Barriers:Tissue barriers · 2022Article
- Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging.Frontiers in aging neuroscience · 2021Article
- Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model.Brain communications · 2021Article
- Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling.Fluids and barriers of the CNS · 2020Article
- Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function.Nature communications · 2020Article
- Multiscale Selectivity and in vivo Biodistribution of NRP-1International journal of nanomedicine · 2020Article
- Managing Chronic Non-Malignant Pain in the Elderly: Intrathecal Therapy.Drugs & aging · 2019Review
- Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review.Frontiers in molecular neuroscience · 2019Article
- Perfusion magnetic resonance imaging in pediatric brain tumors.Neuroradiology · 2017Article
- Diffusion-weighted magnetic resonance imaging in the assessment of choroid plexus aging.The neuroradiology journal · 2017Article
- Age-related changes in brain hemodynamics; A calibrated MRI study.Human brain mapping · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe cerebrospinal fluid (CSF) plays a major role in the physiology of the central nervous system. The continuous turnover of CSF is mainly attributed to the highly vascularized choroid plexus (CP) located in the cerebral ventricles which represent a complex interface between blood and CSF. We propose a method for evaluating CP functionality in vivo using perfusion MR imaging and establish the age-related changes of associated parameters.
methodsFifteen patients with small intracranial tumors were retrospectively studied. MR Imaging was performed on a 3T MR Scanner. Gradient-echo echo planar images were acquired after bolus injection of gadolinium-based contrast agent (CA). The software developed used the combined T1- and T2-effects. The decomposition of the relaxivity signals enables the calculation of the CP capillary permeability (K2). The relative cerebral blood volume (rCBV), mean transit time (MTT), and signal slope decrease (SSD) were also calculated.
resultsThe mean permeability K2 of the extracted CP was 0.033+/-0.18 s(-1). K2 and SSD significantly decreased with subject's age whereas MTT significantly increased with subject's age. No significant correlation was found for age-related changes in rCBV and rCBF.
conclusionThe decrease in CP permeability is in line with the age-related changes in CSF secretion observed in animals. The MTT increase indicates significant structural changes corroborated by microscopy studies in animals or humans. Overall, DSC MR-perfusion enables an in vivo evaluation of the hemodynamic state of CP. Clinical applications such as neurodegenerative diseases could be considered thanks to specific functional studies of CP.
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