ArticleMolecular systems biology2013
Sequential induction of auxin efflux and influx carriers regulates lateral root emergence.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Regulatory Mechanism of the GmMYB14 Transcription Factor on Auxin-Related Proteins in Soybean.International journal of molecular sciences · 2025Article
- Auxin-mediated stress relaxation in pericycle and endoderm remodeling drives lateral root initiation.Biophysical journal · 2025Article
- Lights, location, action: shade avoidance signalling over spatial scales.Journal of experimental botany · 2025Review
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
- Transcriptome Analysis of Early Lateral Root Formation in Tomato.Plants (Basel, Switzerland) · 2024Article
- Article
- Auxin as an architect of the pectin matrix.Journal of experimental botany · 2023Review
- PUCHI represses early meristem formation in developing lateral roots of Arabidopsis thaliana.Journal of experimental botany · 2022Article
- Auxin in Root Development.Cold Spring Harbor perspectives in biology · 2022Review
- Modeling Auxin Signaling in Roots: Auxin Computations.Cold Spring Harbor perspectives in biology · 2022Review
- Comparative transcriptome analysis and identification of candidate adaptive evolution genes ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Auxin-Regulated Lateral Root Organogenesis.Cold Spring Harbor perspectives in biology · 2021Review
- TheQuantitative plant biology · 2021Review
- Phytohormones Trigger Drought Tolerance in Crop Plants: Outlook and Future Perspectives.Frontiers in plant science · 2021Review
- A tetraspanin gene regulating auxin response and affecting orchid perianth size and various plant developmental processes.Plant direct · 2019Article
- Transcriptional regulation of MdPIN3 and MdPIN10 by MdFLP during apple self-rooted stock adventitious root gravitropism.BMC plant biology · 2019Article
- LBD16 and LBD18 acting downstream of ARF7 and ARF19 are involved in adventitious root formation in Arabidopsis.BMC plant biology · 2019Article
- Interplay of Auxin and Cytokinin in Lateral Root Development.International journal of molecular sciences · 2019Review
- Plant Aquaporins in Infection by and Immunity Against Pathogens - A Critical Review.Frontiers in plant science · 2019Article
- Intracellularly Localized PIN-FORMED8 Promotes Lateral Root Emergence inFrontiers in plant science · 2019Article
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26 authors.
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Abstract
In Arabidopsis, lateral roots originate from pericycle cells deep within the primary root. New lateral root primordia (LRP) have to emerge through several overlaying tissues. Here, we report that auxin produced in new LRP is transported towards the outer tissues where it triggers cell separation by inducing both the auxin influx carrier LAX3 and cell-wall enzymes. LAX3 is expressed in just two cell files overlaying new LRP. To understand how this striking pattern of LAX3 expression is regulated, we developed a mathematical model that captures the network regulating its expression and auxin transport within realistic three-dimensional cell and tissue geometries. Our model revealed that, for the LAX3 spatial expression to be robust to natural variations in root tissue geometry, an efflux carrier is required--later identified to be PIN3. To prevent LAX3 from being transiently expressed in multiple cell files, PIN3 and LAX3 must be induced consecutively, which we later demonstrated to be the case. Our study exemplifies how mathematical models can be used to direct experiments to elucidate complex developmental processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.