SynthesisInternational journal of colorectal disease2014
Systematic review: anal and rectal changes after radiotherapy for prostate cancer.
Synthesis in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Fecal incontinence after prostate cancer irradiation: a systematic literature review.Prostate cancer and prostatic diseases · 2026Pooled it
- Pooled it
- A Systematic Post-QUANTEC Review of Tolerance Doses for Late Toxicity After Prostate Cancer Radiation Therapy.International journal of radiation oncology, biology, physics · 2018Pooled it
- Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers.The Cochrane database of systematic reviews · 2018Pooled it
- Secondary Cancers After Radiation Therapy for Primary Prostate or Rectal Cancer.World journal of surgery · 2016Pooled it
- Effects of radiation therapy on the structure and function of the pelvic floor muscles of patients with cancer in the pelvic area: a systematic review.Journal of cancer survivorship : research and practice · 2016Pooled it
- Unrecognized sexual dysfunction in gay and bisexual men after prostate cancer treatment: the antecedents and impact of anodyspareunia.The journal of sexual medicine · 2023Trial
- Transformer-based prediction of radiotherapy couch shift risk in prostate cancer based on rectal volume.Scientific reports · 2026Article
- Machine-learning with multiomics for radiotherapy-induced acute rectal toxicities and survival outcome in patients with cervical cancer.Radiation oncology (London, England) · 2026Article
- Identifying the optimal time point for adaptive re-planning in prostate cancer radiotherapy to minimise rectal toxicity using normal tissue imaging biomarkers.Physics and imaging in radiation oncology · 2025Article
- Risk factors for rectal bleeding in prostate cancer after radiotherapy with a validation of current rectal dose constraints.Acta oncologica (Stockholm, Sweden) · 2025Article
- Investigation of pelvic floor influence on prostate displacement in image-guided radiotherapy.The Prostate · 2025Article
- High-risk factors and predictive models for hemorrhagic chronic radiation proctitis.European journal of medical research · 2025Article
- Review
- Pelvic Floor Therapy and Initial Interventions for Pelvic Floor Dysfunction in Gynecologic Malignancies.Current oncology reports · 2024Review
- Administration of modified Gegen Qinlian decoction for hemorrhagic chronic radiation proctitis: A case report and review of literature.World journal of clinical cases · 2023Article
- Faecal incontinence in adults.Nature reviews. Disease primers · 2022Review
- Burden of disease experienced by patients following a watch-and-wait policy for locally advanced rectal cancer: A qualitative study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Rectal irrigation as rescue therapy for refractory and severe hemorrhagic radiation proctitis: A case report.Clinical case reports · 2021Article
- Sexual aspects of shared decision making and prehabilitation in men diagnosed with prostate cancer.International journal of impotence research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePelvic radiotherapy may lead to changes of anorectal function resulting in incontinence-related complaints. The aim of this study was to systematically review objective findings of late anorectal physiology and mucosal appearance after irradiation for prostate cancer.
methodsMEDLINE, EMBASE, and the Cochrane library were searched. Original articles in which anal function, rectal function, or rectal mucosa were examined ≥3 months after EBRT for prostate cancer were included.
resultsTwenty-one studies were included with low to moderate quality. Anal resting pressures significantly decreased in 6 of the 9 studies including 277 patients. Changes of squeeze pressure and rectoanal inhibitory reflex were less uniform. Rectal distensibility was significantly impaired after EBRT in 7 of 9 studies (277 patients). In 4 of 9 studies on anal and in 5 of 9 on rectal function, disturbances were associated with urgency, frequent bowel movements or fecal incontinence. Mucosal changes as assessed by the Vienna Rectoscopy Score revealed telangiectasias in 73 %, congestion in 33 %, and ulceration in 4 % of patients in 8 studies including 346 patients, but no strictures or necrosis. Three studies reported mucosal improvement during follow-up. Telangiectasias, particularly multiple, were associated with rectal bleeding. Not all bowel complaints (30 %) were related to radiotherapy.
conclusionsLow to moderate quality evidence indicates that EBRT reduces anal resting pressure, decreases rectal distensibility, and frequently induces telangiectasias of rectal mucosa. Objective changes may be associated with fecal incontinence, urgency, frequent bowel movements, and rectal bleeding, but these symptoms are not always related to radiation damage.
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