ArticleSmall GTPases
The CASZ1/Egfl7 transcriptional pathway is required for RhoA expression in vascular endothelial cells.
Article in Small GTPases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Role of the CASZ1 transcription factor in tissue development and disease.European journal of medical research · 2023Review
- Review
- The role of microfibrillar-associated protein 2 in cancer.Frontiers in oncology · 2022Review
- The Prognostic Significance of Protein Expression of CASZ1 in Clear Cell Renal Cell Carcinoma.Disease markers · 2019Article
- Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling.Journal of experimental & clinical cancer research : CR · 2018Article
- Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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3 authors at 2 institutions in 1 country.
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Abstract
Vertebrate development depends on the formation of a closed circulatory loop consisting of intricate networks of veins, arteries, and lymphatic vessels. The coordinated participation of multiple molecules including growth factors, transcription factors, extracellular matrix proteins, and regulators of signaling such as small GTPases is essential for eliciting the desired cellular behaviors associated with vascular assembly and morphogenesis. We have recently demonstrated that a novel transcriptional pathway involving activation of the Epidermal Growth Factor-like Domain 7 (Egfl7) gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis. Furthermore, this transcriptional network promotes RhoA expression and subsequent GTPase activity linking transcriptional regulation of endothelial gene expression to direct physiological outputs associated with Rho GTPase signaling, i.e., cell adhesion and cytoskeletal dynamics. Here we will discuss our studies with respect to our current understanding of the mechanisms underlying regulation of RhoA transcription, protein synthesis, and activity.
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