ArticleMolecular biology and evolution2014
Massive habitat-specific genomic response in D. melanogaster populations during experimental evolution in hot and cold environments.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed.
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
- Quantifying the Evolutionary Potential for Delta Smelt Persistence in a Warming Habitat.Evolutionary applications · 2026Article
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Quantifying the evolutionary potential for Delta Smelt persistence in a warming habitat.bioRxiv : the preprint server for biology · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Insect Models to Study Human Lipid Metabolism Disorders.Advances in experimental medicine and biology · 2026Review
- Repeatability of evolution and genomic predictions of temperature adaptation in seed beetles.Nature ecology & evolution · 2025Article
- Article
- Experimental Evolution in a Warming World: The Omics Era.Molecular biology and evolution · 2024Review
- A Path Integral Approach for Allele Frequency Dynamics Under Polygenic Selection.bioRxiv : the preprint server for biology · 2024Article
- Genomics for monitoring and understanding species responses to global climate change.Nature reviews. Genetics · 2024Review
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Natural alleles at theProceedings. Biological sciences · 2022Article
- Experimental evolution reveals the synergistic genomic mechanisms of adaptation to ocean warming and acidification in a marine copepod.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Understanding the biology of species' ranges: when and how does evolution change the rules of ecological engagement?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Loss of transcriptional plasticity but sustained adaptive capacity after adaptation to global change conditions in a marine copepod.Nature communications · 2022Article
- Crossing design shapes patterns of genetic variation in synthetic recombinant populations of Saccharomyces cerevisiae.Scientific reports · 2021Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation ineLife · 2021Article
- Experimental evolution supports signatures of sexual selection in genomic divergence.Evolution letters · 2021Article
23 more citing papers are in PubMed but not listed here.
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Abstract
Experimental evolution in combination with whole-genome sequencing (evolve and resequence [E&R]) is a promising approach to define the genotype-phenotype map and to understand adaptation in evolving populations. Many previous studies have identified a large number of putative selected sites (i.e., candidate loci), but it remains unclear to what extent these loci are genuine targets of selection or experimental noise. To address this question, we exposed the same founder population to two different selection regimes-a hot environment and a cold environment-and quantified the genomic response in each. We detected large numbers of putative selected loci in both environments, albeit with little overlap between the two sets of candidates, indicating that most resulted from habitat-specific selection. By quantifying changes across multiple independent biological replicates, we demonstrate that most of the candidate SNPs were false positives that were linked to selected sites over distances much larger than the typical linkage disequilibrium range of Drosophila melanogaster. We show that many of these mid- to long-range associations were attributable to large segregating inversions and confirm by computer simulations that such patterns could be readily replicated when strong selection acts on rare haplotypes. In light of our findings, we outline recommendations to improve the performance of future Drosophila E&R studies which include using species with negligible inversion loads, such as D. mauritiana and D. simulans, instead of D. melanogaster.
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