ArticleHeredity2014
The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025Article
- Molecular evolution and genetic diversity of defective chorion 1 in Anastrepha fraterculus and Anastrepha obliqua (Diptera, Tephritidae).Development genes and evolution · 2024Article
- Genetic Coupling of Mate Recognition Systems in the Genomic Era.Cold Spring Harbor perspectives in biology · 2024Review
- The role ofScience advances · 2024Article
- Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.Science advances · 2023Article
- Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte nuclear factor 4.bioRxiv : the preprint server for biology · 2023Article
- Recurrent erosion of COA1/MITRAC15 exemplifies conditional gene dispensability in oxidative phosphorylation.Scientific reports · 2021Article
- A non-coding indel polymorphism in theProceedings. Biological sciences · 2021Article
- Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.Current biology : CB · 2014Article
- Functional Implications of RNA Splicing for Human Long Intergenic Noncoding RNAs.Evolutionary bioinformatics online · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been much debate concerning whether cis-regulatory or coding changes are more likely to produce evolutionary innovation or adaptation in gene function, but an additional complication is that some genes can dramatically diverge through alternative splicing, increasing the diversity of gene function within a locus. The fruitless gene is a major transcription factor with a wide range of pleiotropic functions, including a fundamental conserved role in sexual differentiation, species-specific morphology and an important influence on male sexual behaviour. Here, we examine the structure of fruitless in multiple species of Drosophila, and determine the patterns of selective constraint acting across the coding region. We found that the pattern of selection, estimated from the ratio of non-synonymous to synonymous substitutions, varied considerably across the gene, with most regions of the gene evolutionarily conserved but with several regions showing evidence of divergence as a result of positive selection. The regions that showed evidence of positive selection were found to be localised to relatively consistent regions across multiple speciation events, and are associated with alternative splicing. Alternative splicing may thus provide a route to gene diversification in key regulatory loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.