ArticleHeredity2014
Estimating genome-wide heterozygosity: effects of demographic history and marker type.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot.Molecular ecology · 2026Article
- Exploiting historical agronomic data to develop genomic prediction strategies for early clonal selection in the Louisiana sugarcane variety development program.The plant genome · 2025Article
- Article
- Population variability in X-chromosome inactivation across 10 mammalian species.Nature communications · 2024Article
- Population genetic structure in a self-compatible hermaphroditic snail is driven by drift independently of its contemporary mating system.Ecology and evolution · 2024Article
- Comparative Analysis of Microsatellite and SNP Markers for Genetic Management of Red Deer.Animals : an open access journal from MDPI · 2023Article
- Population variability in X-chromosome inactivation across 9 mammalian species.bioRxiv : the preprint server for biology · 2023Article
- Parsing variance by marker type: Testing biogeographic hypotheses and differential contribution of historical processes to population structure in a desert lizard.Molecular ecology · 2023Article
- Evidence of an Absence of Inbreeding Depression in a Wild Population of Weddell Seals (Entropy (Basel, Switzerland) · 2023Article
- Relationship between genome-wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate.Ecology and evolution · 2022Article
- Article
- Genome-wide diversity and habitat underlie fine-scale phenotypic differentiation in the rainbow darter (Evolutionary applications · 2021Article
- An empirical comparison of population genetic analyses using microsatellite and SNP data for a species of conservation concern.BMC genomics · 2020Article
- Genome-wide association study identified candidate genes controlling continuous storage root formation and bulking in hexaploid sweetpotato.BMC plant biology · 2020Article
- Individual Heterozygosity Influences Arrival Times and Mating Success of Male Red-Breasted FlycatchersZoological studies · 2020Article
- An evaluation of sequencing coverage and genotyping strategies to assess neutral and adaptive diversity.Molecular ecology resources · 2019Article
- Length polymorphisms at two candidate genes explain variation of migratory behaviors in blackpoll warblers (Ecology and evolution · 2019Article
- From microsatellites to single nucleotide polymorphisms for the genetic monitoring of a critically endangered sturgeon.Ecology and evolution · 2019Article
- Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon.BMC ecology · 2019Article
- Comparing RADseq and microsatellites for estimating genetic diversity and relatedness - Implications for brown trout conservation.Ecology and evolution · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterozygosity-fitness correlations (HFCs) are often used to link individual genetic variation to differences in fitness. However, most studies examining HFCs find weak or no correlations. Here, we derive broad theoretical predictions about how many loci are needed to adequately measure genomic heterozygosity assuming different levels of identity disequilibrium (ID), a proxy for inbreeding. We then evaluate the expected ability to detect HFCs using an empirical data set of 200 microsatellites and 412 single nucleotide polymorphisms (SNPs) genotyped in two populations of bighorn sheep (Ovis canadensis), with different demographic histories. In both populations, heterozygosity was significantly correlated across marker types, although the strength of the correlation was weaker in a native population compared with one founded via translocation and later supplemented with additional individuals. Despite being bi-allelic, SNPs had similar correlations to genome-wide heterozygosity as microsatellites in both populations. For both marker types, this association became stronger and less variable as more markers were considered. Both populations had significant levels of ID; however, estimates were an order of magnitude lower in the native population. As with heterozygosity, SNPs performed similarly to microsatellites, and precision and accuracy of the estimates of ID increased as more loci were considered. Although dependent on the demographic history of the population considered, these results illustrate that genome-wide heterozygosity, and therefore HFCs, are best measured by a large number of markers, a feat now more realistically accomplished with SNPs than microsatellites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.