ReviewEpigenetics2014
Homeland security in the C. elegans germ line: insights into the biogenesis and function of piRNAs.
Review in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Review
- Neuronal basis and diverse mechanisms of pathogen avoidance inFrontiers in immunology · 2024Review
- Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions.Biochemical Society transactions · 2022Article
- Small RNA pathways in the nematode Ascaris in the absence of piRNAs.Nature communications · 2022Article
- RNA Granules: A View from the RNA Perspective.Molecules (Basel, Switzerland) · 2020Review
- Rapid evolution and conserved function of the piRNA pathway.Open biology · 2019Review
- Transcriptional quiescence in primordial germ cells.Critical reviews in biochemistry and molecular biology · 2018Review
- Article
- Integration site selection by retroviruses and transposable elements in eukaryotes.Nature reviews. Genetics · 2017Review
- CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline.Development (Cambridge, England) · 2015Article
- Endogenous siRNAs: regulators of internal affairs.Biochemical Society transactions · 2014Review
- Germ-granule components prevent somatic development in the C. elegans germline.Current biology : CB · 2014Article
- Elements and machinery of non-coding RNAs: toward their taxonomy.EMBO reports · 2014Review
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
While most eukaryotic genomes contain transposable elements that can provide select evolutionary advantages to a given organism, failure to tightly control the mobility of such transposable elements can result in compromised genomic integrity of both parental and subsequent generations. Together with the Piwi subfamily of Argonaute proteins, small, non-coding Piwi-interacting RNAs (piRNAs) primarily function in the germ line to defend the genome against the potentially deleterious effects that can be caused by transposition. Here, we describe recent discoveries concerning the biogenesis and function of piRNAs in the nematode Caenorhabditis elegans, illuminating how the faithful production of these mature species can impart a robust defense mechanism for the germ line to counteract problems caused by foreign genetic elements across successive generations by contributing to the epigenetic memory of non-self vs. self.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.