ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2013
NMR studies of nucleic acid dynamics.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- RNA circularization preserves dynamics and enables in-cell relaxation NMR.Nucleic acids research · 2026Article
- Article
- Molecular insights into the interaction between a disordered protein and a folded RNA.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Molecular insights into the interaction between a disordered protein and a folded RNA.bioRxiv : the preprint server for biology · 2024Article
- Structural and computational studies of HIV-1 RNA.RNA biology · 2024Review
- Transient Hoogsteen Base Pairs Observed in Unbiased Molecular Dynamics Simulations of DNA.The journal of physical chemistry letters · 2022Article
- Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats.Journal of molecular cell biology · 2019Article
- Helix-Based RNA Landscape Partition and Alternative Secondary Structure Determination.ACS omega · 2019Article
- Advances that facilitate the study of large RNA structure and dynamics by nuclear magnetic resonance spectroscopy.Wiley interdisciplinary reviews. RNA · 2019Review
- Development of Vibrational Frequency Maps for Nucleobases.The journal of physical chemistry. B · 2019Article
- Relating Structure and Dynamics in RNA Biology.Cold Spring Harbor perspectives in biology · 2019Review
- A coarse-grained model for assisting the investigation of structure and dynamics of large nucleic acids by ion mobility spectrometry-mass spectrometry.Physical chemistry chemical physics : PCCP · 2017Article
- Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop.Physical chemistry chemical physics : PCCP · 2017Article
- Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR.The journal of physical chemistry. B · 2017Article
- Structure of a low-population binding intermediate in protein-RNA recognition.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A dynamic look backward and forward.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Review
- The solution structural ensembles of RNA kink-turn motifs and their protein complexes.Nature chemical biology · 2016Article
- Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.Cell reports · 2016Article
- Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions.Journal of biomolecular NMR · 2016Article
- Rich RNA Structure Landscapes Revealed by Mutate-and-Map Analysis.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Nucleic acid structures have to satisfy two diametrically opposite requirements; on one hand they have to adopt well-defined 3D structures that can be specifically recognized by proteins; on the other hand, their structures must be sufficiently flexible to undergo very large conformational changes that are required during key biochemical processes, including replication, transcription, and translation. How do nucleic acids introduce flexibility into their 3D structure without losing biological specificity? Here, I describe the development and application of NMR spectroscopic techniques in my laboratory for characterizing the dynamic properties of nucleic acids that tightly integrate a broad set of NMR measurements, including residual dipolar couplings, spin relaxation, and relaxation dispersion with sample engineering and computational approaches. This approach allowed us to obtain fundamental new insights into directional flexibility in nucleic acids that enable their structures to change in a very specific functional manner.
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Registered trials
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