ArticleInternational psychogeriatrics2013
Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in dementia with Lewy bodies.
Article in International psychogeriatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Cerebral perfusion correlates of domain-specific cognitive function in Alzheimer's disease and dementia with Lewy bodies.Journal of Alzheimer's disease : JAD · 2026Article
- Not always the usual suspect: symptom variations in Parkinson's disease beyond ON-OFF fluctuations.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies.Molecular neurodegeneration · 2025Review
- Distinct eye movement patterns to complex scenes in Alzheimer's disease and Lewy body disease.Frontiers in neuroscience · 2024Article
- The phenotype of delirium based on a close reading of diagnostic criteria.International journal of geriatric psychiatry · 2023Review
- Brain Degeneration in Synucleinopathies Based on Analysis of Cognition and Other Nonmotor Features: A Multimodal Imaging Study.Biomedicines · 2023Article
- Visuo-Perceptual and Decision-Making Contributions to Visual Hallucinations in Mild Cognitive Impairment in Lewy Body Disease: Insights from a Drift Diffusion Analysis.Brain sciences · 2020Article
- Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer's disease and normal aging: implications for fluctuations.Alzheimer's research & therapy · 2020Article
- Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis.Human brain mapping · 2018Article
- Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Molecular Imaging and Updated Diagnostic Criteria in Lewy Body Dementias.Current neurology and neuroscience reports · 2017Review
- Metabolic connectomics targeting brain pathology in dementia with Lewy bodies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease.Human brain mapping · 2016Article
- Thalamic Involvement in Fluctuating Cognition in Dementia with Lewy Bodies: Magnetic Resonance Evidences.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Patterns of cerebellar volume loss in dementia with Lewy bodies and Alzheimer׳s disease: A VBM-DARTEL study.Psychiatry research · 2014Article
- Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle.Frontiers in neurology · 2014Review
- fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies.NeuroImage. Clinical · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFluctuating cognition (FC), particularly in attention, is a core and defining symptom in dementia with Lewy bodies (DLB) but is seen much less frequently in Alzheimer's dementia (AD). However, its neurobiological origin is poorly understood. The aim of our study was therefore to characterize perfusion patterns in DLB patients that are associated with the severity and frequency of FC as measured both clinically and using objective neuropsychological assessments.
methodsSpatial covariance analyses were applied to data derived from single photon emission computed tomography (SPECT) HMPAO brain imaging in 19 DLB and 23 AD patients. Patients underwent clinical assessment of their FC and cognitive function as well as objective testing of their attention.
resultsCovariant perfusion principal components (PCs) were not associated with either FC or cognitive or attentional measures in AD. However, in DLB patients, the second PC (defined as DLB-cognitive motor pattern, DLB-PCI2) which was characterized by bilateral relative increases in cerebellum, basal ganglia, and supplementary motor areas and widespread bilateral decreases in parietal regions, positively correlated with poorer cognitive function, increased FC and worse attentional function measured both clinically and neurophysiologically (p < 0.05) as well as with the severity of bradykinesia (p = 0.04).
conclusionsFC in DLB appears distinct from those seen in AD, and likely to be driven by internal neurobiological perturbations in brain circuitry as evidenced using spatial covariance analyses of cerebral perfusion. FC and certain aspects of attentional dysfunction in DLB may, in part, depend upon both distributed motor and non-motor networks.
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