Evidence map›Paper›PMID 24148695›Full record

Trial reportInternational journal of stroke : official journal of the International Stroke Society2014

Exercise-induced changes in cardiovascular function after stroke: a randomized controlled trial.

Ada Tang, Janice J Eng, Andrei V Krassioukov, Kenneth M Madden, Azam Mohammadi, Michael Y C Tsang, Teresa S M Tsang

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of stroke : official journal of the International Stroke Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03570216 (Acute Effects of High-Intensity Interval Exercise vs. Moderate-Intensity Continuous Exercise on Arterial Stiffness in Chronic Stroke), which is not on this map. Cited by 32 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 12 pooled it
3.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03570216 nacompletednot on this mapstarted 2019, after this paper: background citation

Acute Effects of High-Intensity Interval Exercise vs. Moderate-Intensity Continuous Exercise on Arterial Stiffness in Chronic Stroke

TypeinterventionalSponsorMcMaster UniversityRan2019 to 2020Enrolled4ConditionsStroke, CardiovascularArmsCardiopulmonary exercise test, Moderate-intensity continuous exercise, High-intensity interval exercise
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 12 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  4. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020
    Pooled it
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  6. Pooled it
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  8. Circuit class therapy for improving mobility after stroke.The Cochrane database of systematic reviews · 2017
    Pooled it
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  10. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2016
    Pooled it
  11. Pooled it
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  13. Trial
  14. Trial
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ada TangFaculty of Medicine, Department of Physical Therapy, Vancouver Coastal Health, University of British Columbia, Vancouver, British Columbia, Canada.
Janice J Eng
Andrei V Krassioukov
Kenneth M Madden
Azam Mohammadi
Michael Y C Tsang
Teresa S M Tsang
University of British Columbia · CAVancouver Coastal Health · CAInternational Collaboration On Repair Discoveries · CA

Funding

CIHR 111183-1CIHR MFE-98550CIHR MOP-111183CIHR MSH-63617
6 · The paper itself

Abstract

BACKGROUND AND

aimsCardiovascular co-morbidities are prevalent after stroke, with heart disease, hypertension and impaired glucose tolerance present in the majority of cases. Exercise has the potential to mediate cardiovascular risk factors commonly present in people with stroke. This single-blinded randomized controlled trial compared the effects of high versus low intensity exercise on fitness, cardiovascular risk factors, and cardiac function after stroke.

methodsFifty participants (age 50-80 y, >1 y post-stroke) were randomized to a high-intensity Aerobic Exercise (AE) or low-intensity non-aerobic Balance/Flexibility (BF) program (6 months, 3 60-min sessions/week). Outcomes assessed by VO2 peak (primary outcome), arterial stiffness, ambulatory capacity, hemodynamics and cardiac function using echocardiography, and lipid, glucose and homocysteine levels. Assessors were blinded to group allocation.

resultsTwenty-three (92%) of 25 AE group participants (withdrawals unrelated to the intervention) and all BF group participants completed the program. One BF group participant experienced 2 non-injurious falls during class. No other adverse events occurred. There were no changes in VO2 peak in either group (AE 16·9±7 to 17·4±7 ml●kg(-1) ●min(-1) vs. BF 16·9±6 to 16·6±5 ml●kg(-1) ●min(-1) , P=0·45), but AE group demonstrated greater improvement in right atrial emptying fraction (AE 30±22 to 37±22% vs. BF 35±20 to 31±20%, P=0·04). Both groups demonstrated improvements in lipid profiles, glucose and homocysteine levels, and ambulatory capacity (P<0·04).

conclusionsThis was the first study to examine the effects of aerobic exercise after stroke on cardiovascular hemodynamics. High-intensity exercise improved right-sided function and early myocardial relaxation. Low-intensity exercise may also benefit plasma lipid, glucose and inflammatory markers, and ambulatory capacity. This study is an important step towards understanding mechanisms by which exercise may reduce cardiovascular risk and function.

Indexed as

Cardiovascular Physiological PhenomenaStroke RehabilitationAgedAged, 80 and overBiomarkersBlood PressureEchocardiography, DopplerExerciseExercise TestExercise TherapyFemaleHemodynamicsHumansMaleMiddle AgedSingle-Blind MethodBiomarkersclinical trialexerciserehabilitationrisk factorssonographystroke

Identifiers

PMID24148695
PMCPMC4486377
OpenAlexW2027995666

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.