ArticleBMC genomics2013
DNA repair in Mycoplasma gallisepticum.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
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- WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium.Frontiers in microbiology · 2024Article
- Gene Silencing through CRISPR Interference in Mycoplasmas.Microorganisms · 2022Article
- Thymidine utilisation pathway is a novel phenotypic switch ofJournal of medical microbiology · 2022Article
- Role of DNA modifications in Mycoplasma gallisepticum.PloS one · 2022Article
- The Dynamics ofFrontiers in microbiology · 2021Article
- Propionate Induces Virulent Properties of Crohn's Disease-AssociatedFrontiers in microbiology · 2020Article
- Data-independent proteome profile ofData in brief · 2018Article
- Response induced in Mycoplasma gallisepticum under heat shock might be relevant to infection process.Scientific reports · 2017Article
- Transcription profiling data set of different states ofGenomics data · 2017Article
- Data on genome analysis ofData in brief · 2017Article
- Structural basis of the high thermal stability of the histone-like HU protein from the mollicute Spiroplasma melliferum KC3.Scientific reports · 2016Article
- Phase Transition of the Bacterium upon Invasion of a Host Cell as a Mechanism of Adaptation: a Mycoplasma gallisepticum Model.Scientific reports · 2016Article
- Reconstruction of Transcription Control Networks in Mollicutes by High-Throughput Identification of Promoters.Frontiers in microbiology · 2016Article
- Global Changes in Mycoplasma gallisepticum Phase-Variable Lipoprotein Gene vlhA Expression during In Vivo Infection of the Natural Chicken Host.Infection and immunity · 2016Article
- Comparative genomic analysis of seven Mycoplasma hyosynoviae strains.MicrobiologyOpen · 2015Article
- Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the histone-like HU protein from Spiroplasma melliferum KC3.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Transcriptome analysis reveals novel regulatory mechanisms in a genome-reduced bacterium.Nucleic acids research · 2014Article
- Metabolomic analysis of three Mollicute species.PloS one · 2014Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDNA repair is essential for the maintenance of genome stability in all living beings. Genome size as well as the repertoire and abundance of DNA repair components may vary among prokaryotic species. The bacteria of the Mollicutes class feature a small genome size, absence of a cell wall, and a parasitic lifestyle. A small number of genes make Mollicutes a good model for a "minimal cell" concept.
resultsIn this work we studied the DNA repair system of Mycoplasma gallisepticum on genomic, transcriptional, and proteomic levels. We detected 18 out of 22 members of the DNA repair system on a protein level. We found that abundance of the respective mRNAs is less than one per cell. We studied transcriptional response of DNA repair genes of M. gallisepticum at stress conditions including heat, osmotic, peroxide stresses, tetracycline and ciprofloxacin treatment, stationary phase and heat stress in stationary phase.
conclusionsBased on comparative genomic study, we determined that the DNA repair system M. gallisepticum includes a sufficient set of proteins to provide a cell with functional nucleotide and base excision repair and mismatch repair. We identified SOS-response in M. gallisepticum on ciprofloxacin, which is a known SOS-inducer, tetracycline and heat stress in the absence of established regulators. Heat stress was found to be the strongest SOS-inducer. We found that upon transition to stationary phase of culture growth transcription of DNA repair genes decreases dramatically. Heat stress does not induce SOS-response in a stationary phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.