SynthesisBMC nephrology2013
Association of frailty and physical function in patients with non-dialysis CKD: a systematic review.
Synthesis in BMC nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Frailty and mortality among patients with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis.International urology and nephrology · 2020Pooled it
- The Relevance of Geriatric Impairments in Patients Starting Dialysis: A Systematic Review.Clinical journal of the American Society of Nephrology : CJASN · 2016Pooled it
- Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.Journal of the American Society of Nephrology : JASN · 2020Trial
- Article
- The electronic frailty index indicates mortality risk in end stage kidney disease patients on haemodialysis: retrospective survival analyses using linked data from two sources.Clinical kidney journal · 2026Article
- The prevalence and burden of chronic kidney disease, patterns of anticoagulation prescribing, and major bleeding risk in older adults with atrial fibrillation.BMC geriatrics · 2025Article
- Finerenone and Clinical Outcomes in CKD and Type 2 Diabetes by Frailty Index: FIDELITY Post Hoc Analysis.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Office and home blood pressure and their difference according to frailty status among community-dwelling older adults: the NOSE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Early Evaluation of the Short Physical Performance Battery in Hospitalized Patients with Chronic Kidney Disease Predicts Long-Term Hospitalization.Diseases (Basel, Switzerland) · 2025Article
- SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.Scientific reports · 2025Observational
- Association Between Albuminuria and Glomerular Filtration Rate With Incident Frailty.Kidney international reports · 2025Article
- Factors Associated with Frailty Transitions Using the Kihon Checklist: A 6-Year Longitudinal Study Among Japanese Residents.Clinical interventions in aging · 2025Article
- High-resistance inspiratory muscle strength training: a promising strategy for improving vascular health in chronic kidney disease.Frontiers in physiology · 2025Article
- Association of frailty with functional difficulty in older Ghanaians: stability between women and men in two samples with different income levels.BMC geriatrics · 2024Article
- Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults.BMC geriatrics · 2024Article
- Frailty and associated outcomes in patients undergoing percutaneous left atrial appendage occlusion: findings from the NCDR LAAO registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis.Frontiers in medicine · 2024Review
- Resilience, activities of daily living, and well-being in patients with chronic kidney disease.Nursing open · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is a condition characterized by a decline in physical function and functional capacity. Common symptoms of frailty, such as weakness and exhaustion, are prevalent in patients with chronic kidney disease (CKD). The increased vulnerability of frail patients with coexisting CKD may place them at a heightened risk of encountering additional health complications. The purpose of this systematic review was to explore the link between frailty, CKD and clinical outcomes.
methodsWe searched for cross sectional and prospective studies in the general population and in the CKD population indexed in EMBASE, Pubmed, Web of Science, CINAHL, Cochrane and Ageline examining the association between frailty and CKD and those relating frailty in patients with CKD to clinical outcomes.
resultsWe screened 5,066 abstracts and retrieved 108 studies for full text review. We identified 7 studies associating frailty or physical function to CKD. From the 7 studies, we identified only two studies that related frailty in patients with CKD to a clinical outcome. CKD was consistently associated with increasing frailty or reduced physical function [odds ratios (OR) 1.30 to 3.12]. In patients with CKD, frailty was associated with a greater than two-fold higher risk of dialysis and/or death [OR from 2.0 to 5.88].
conclusionsCKD is associated with a higher risk of frailty or diminished physical function. Furthermore, the presence of frailty in patients with CKD may lead to a higher risk of mortality. Further research must be conducted to understand the mechanisms of frailty in CKD and to confirm its association with clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.