ArticleAnnals of the New York Academy of Sciences2013
Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation.
Article in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Nociceptin/orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli.Translational psychiatry · 2026Article
- Age-specific sex effects in extinction of conditioned fear in rodents.Frontiers in behavioral neuroscience · 2023Article
- Computational modeling of interventions for developmental disorders.Psychological review · 2019Article
- BDNF ValNeuroImage · 2017Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats.Frontiers in behavioral neuroscience · 2017Article
- Neural signals of vicarious extinction learning.Social cognitive and affective neuroscience · 2016Article
- Individual differences in learning predict the return of fear.Learning & behavior · 2015Article
- Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Environmental and Genetic Influences on Neurocognitive Development: The Importance of Multiple Methodologies and Time-Dependent Intervention.Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Anxiety disorders are the most common psychiatric disorders, affecting as many as 10% of youth, with diagnoses peaking during adolescence. A core component of these disorders is an unremitting fear in the absence of present threat. One of the most commonly used therapies to treat these disorders is exposure-based cognitive behavioral therapy that identifies the source of the fear and anxiety and then desensitizes the individual to it. This treatment builds on basic principles of fear-extinction learning. A number of patients improve with this therapy, but 40-50% do not. This paper provides an overview of recent empirical studies employing both human imaging and cross-species behavioral genetics to examine how fear regulation varies across individuals and across development, especially during adolescence. These studies have important implications for understanding who may be at risk for anxiety disorders and for whom and when during development exposure-based therapies may be most effective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.