ArticlePflugers Archiv : European journal of physiology1985
Sodium conductance and the activation potential in Xenopus laevis eggs.
Article in Pflugers Archiv : European journal of physiology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Ion channels and signaling pathways used in the fast polyspermy block.Molecular reproduction and development · 2020Review
- Phosphoinositides modulate the voltage dependence of two-pore channel 3.The Journal of general physiology · 2019Article
- The effective membrane capacity of Xenopus eggs: its relations with membrane conductance and cortical granule exocytosis.Pflugers Archiv : European journal of physiology · 1985Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Experiments have been performed to identify the membrane permeability changes causing activation potential in Xenopus eggs. The eggs were artificially activated either by pricking or by addition of the Ca2+ ionophore A23187 to the bath. Two different ionic currents appear to control the activation potential: (i) a chloride current which develops after a delay of 30 s to 5 min from the activating stimulus and which, in low external chloride, produces a depolarization and, (ii) a voltage-dependent outward current which begins to flow when the membrane potential is more positive than about +20 mV and tends to hyperpolarize the membrane. The chloride current lasts about 3-4 min; the voltage-dependent outward current is present before activation and disappears more slowly than the Cl- current. Changes in external sodium concentration affect the reversal potential of the outward current before and after the development of the inward Cl- current. We suggest that the chloride current has the role of producing a rapid depolarization necessary to block polyspermy, while the voltage-dependent sodium outward current might prevent the depolarization from reaching excessively high values and help the repolarization phase.
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