ArticlePLoS neglected tropical diseases2013
Multilocus analysis of divergence and introgression in sympatric and allopatric sibling species of the Lutzomyia longipalpis complex in Brazil.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
- Sex differentiation, divergence, and introgression in the leishmaniasis vectorbioRxiv : the preprint server for biology · 2025Article
- The Lutzomyia longipalpis complex: what's next?Trends in parasitology · 2025Review
- Timing and Pattern of Early Diversification in Drosophilidae (Diptera).Molecular biology and evolution · 2025Article
- Assessing Wolbachia circulation in wild populations of phlebotomine sand flies from Spain and Morocco: implications for control of leishmaniasis.Parasites & vectors · 2025Article
- Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World.PLoS neglected tropical diseases · 2023Article
- Molecular diversity of genes related to biological rhythms (period and timeless) and insecticide resistance (Na V and ace-1) in Anopheles darlingi.Memorias do Instituto Oswaldo Cruz · 2023Article
- Identification of the sex chromosome system in a sand fly species, Lutzomyia longipalpis s.l.G3 (Bethesda, Md.) · 2021Article
- Molecular signatures of sexual communication in the phlebotomine sand flies.PLoS neglected tropical diseases · 2020Article
- Altitude and hillside orientation shapes the population structure of the Leishmania infantum vector Phlebotomus ariasi.Scientific reports · 2020Article
- Phylogenetic relationships of closely-related phlebotomine sand flies (Diptera: Psychodidae) of Nyssomyia genus and Lutzomyia subgenus.Memorias do Instituto Oswaldo Cruz · 2020Article
- Article
- Genetic diversity, phylogeography and molecular clock of the Lutzomyia longipalpis complex (Diptera: Psychodidae).PLoS neglected tropical diseases · 2018Article
- Ecological parameters of the (S)-9-methylgermacrene-B population of the Lutzomyia longipalpis complex in a visceral leishmaniasis area in São Paulo state, Brazil.Parasites & vectors · 2017Article
- The current status of the Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) species complex.Memorias do Instituto Oswaldo Cruz · 2017Review
- The Lutzomyia longipalpis complex: a brief natural history of aggregation-sex pheromone communication.Parasites & vectors · 2016Review
- Clocks do not tick in unison: isolation of Clock and vrille shed new light on the clockwork model of the sand fly Lutzomyia longipalpis.Parasites & vectors · 2015Article
- Phenotypic differentiation in love song traits among sibling species of the Lutzomyia longipalpis complex in Brazil.Parasites & vectors · 2015Article
- Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil.PLoS neglected tropical diseases · 2015Article
- DNA Barcoding of Neotropical Sand Flies (Diptera, Psychodidae, Phlebotominae): Species Identification and Discovery within Brazil.PloS one · 2015Article
- Sex and rhythms in sandflies and mosquitoes: an appreciation of the work of Alexandre Afranio Peixoto (1963-2013).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLutzomyia longipalpis, the main vector of visceral leishmaniasis in Latin America, is a complex of sibling species. In Brazil, a number of very closely related sibling species have been revealed by the analyses of copulation songs, sex pheromones and molecular markers. However, the level of divergence and gene flow between the sibling species remains unclear. Brazilian populations of this vector can be divided in two main groups: one producing Burst-type songs and the Cembrene-1 pheromone and a second more diverse group producing various Pulse song subtypes and different pheromones. METHODOLOGY/PRINCIPAL
findingsWe analyzed 21 nuclear loci in two pairs of Brazilian populations: two sympatric populations from the Sobral locality (1S and 2S) in northeastern Brazil and two allopatric populations from the Lapinha and Pancas localities in southeastern Brazil. Pancas and Sobral 2S are populations of the Burst/Cembrene-1 species while Lapinha and Sobral 1S are two putative incipient species producing the same pheromone and similar Pulse song subtypes. The multilocus analysis strongly suggests the occurrence of gene flow during the divergence between the sibling species, with different levels of introgression between loci. Moreover, this differential introgression is asymmetrical, with estimated gene flow being higher in the direction of the Burst/Cembrene-1 species. CONCLUSIONS/SIGNIFICANCE: The results indicate that introgressive hybridization has been a crucial phenomenon in shaping the genome of the L. longipalpis complex. This has possible epidemiological implications and is particularly interesting considering the potential for increased introgression caused by man-made environmental changes and the current trend of leishmaniasis urbanization in Brazil.
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