ArticlePloS one2013
Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation.Scientific reports · 2019Article
- Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.Stem cell reports · 2018Article
- Article
- Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation.Developmental biology · 2016Article
- Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model.Toxics · 2016Article
- Centroacinar cells: At the center of pancreas regeneration.Developmental biology · 2016Review
- The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish.PLoS genetics · 2015Article
- Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration.Diabetes · 2015Article
- Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration.BMC biology · 2015Article
- The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study.BMC cancer · 2015Article
- Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Differential levels of Neurod establish zebrafish endocrine pancreas cell fates.Developmental biology · 2015Article
- Novel prognostic markers revealed by a proteomic approach separating benign from malignant insulinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.Developmental biology · 2014Article
- Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development.Developmental biology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aldh1 expression is known to mark candidate progenitor populations in adult and embryonic mouse pancreas, and Aldh1 enzymatic activity has been identified as a potent regulator of pancreatic endocrine differentiation in zebrafish. However, the location and identity of Aldh1-expressing cells in zebrafish pancreas remain unknown. In this study we demonstrate that Aldh1-expressing cells are located immediately adjacent to 2F11-positive pancreatic ductal epithelial cells, and that their abundance dramatically increases during zebrafish secondary islet formation. These cells also express neurod, a marker of endocrine progenitor cells, but do not express markers of more mature endocrine cells such as pax6b or insulin. Using formal cre/lox-based lineage tracing, we further show that Aldh1-expressing pancreatic epithelial cells are the direct progeny of pancreatic notch-responsive progenitor cells, identifying them as a critical intermediate between multi-lineage progenitors and mature endocrine cells. Pharmacologic manipulation of Aldh1 enzymatic activity accelerates cell entry into the Aldh1-expressing endocrine progenitor pool, and also leads to the premature maturation of these cells, as evidenced by accelerated pax6b expression. Together, these findings suggest that Aldh1-expressing cells act as both participants and regulators of endocrine differentiation during zebrafish secondary islet formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.