ArticlePloS one2013
Head movements evoked in alert rhesus monkey by vestibular prosthesis stimulation: implications for postural and gaze stabilization.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation
Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
Vestibular Implantation in Older Adults
Long Term Outcomes After Vestibular Implantation
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- [Recent progress in vestibular prosthesis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Effect of a False Inertial Cue in the Velocity-Storage Circuit on Head Posture and Inertia Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.Frontiers in integrative neuroscience · 2023Article
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Head movement kinematics are altered during balance stability exercises in individuals with vestibular schwannoma.Journal of neuroengineering and rehabilitation · 2022Article
- A prosthesis utilizing natural vestibular encoding strategies improves sensorimotor performance in monkeys.PLoS biology · 2022Article
- Proprioception and the predictive sensing of active self-motion.Current opinion in physiology · 2021Article
- Differences in Vestibular-Evoked Myogenic Potential Responses by Using Cochlear Implant and Otolith Organ Direct Stimulation.Frontiers in neurology · 2021Article
- Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.Journal of neurology · 2020Article
- Binocular 3D otolith-ocular reflexes: responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.Journal of neurophysiology · 2020Article
- Cervical myogenic potentials and controlled postural responses elicited by a prototype vestibular implant.Journal of neurology · 2019Article
- Age-related reweighting of visual and vestibular cues for vertical perception.Journal of neurophysiology · 2019Article
- Analysis of sensory system aspects of postural stability during quiet standing in adolescent idiopathic scoliosis patients.Journal of neuroengineering and rehabilitation · 2018Article
- Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future.Frontiers in neurology · 2018Review
- Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.Scientific reports · 2017Article
- Vestibular ablation and a semicircular canal prosthesis affect postural stability during head turns.Experimental brain research · 2016Article
- Galvanic Vestibular Stimulation: Cellular Substrates and Response Patterns of Neurons in the Vestibulo-Ocular Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Analysis of walking variability through simultaneous evaluation of the head, lumbar, and lower-extremity acceleration in healthy youth.Journal of physical therapy science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The vestibular system detects motion of the head in space and in turn generates reflexes that are vital for our daily activities. The eye movements produced by the vestibulo-ocular reflex (VOR) play an essential role in stabilizing the visual axis (gaze), while vestibulo-spinal reflexes ensure the maintenance of head and body posture. The neuronal pathways from the vestibular periphery to the cervical spinal cord potentially serve a dual role, since they function to stabilize the head relative to inertial space and could thus contribute to gaze (eye-in-head + head-in-space) and posture stabilization. To date, however, the functional significance of vestibular-neck pathways in alert primates remains a matter of debate. Here we used a vestibular prosthesis to 1) quantify vestibularly-driven head movements in primates, and 2) assess whether these evoked head movements make a significant contribution to gaze as well as postural stabilization. We stimulated electrodes implanted in the horizontal semicircular canal of alert rhesus monkeys, and measured the head and eye movements evoked during a 100 ms time period for which the contribution of longer latency voluntary inputs to the neck would be minimal. Our results show that prosthetic stimulation evoked significant head movements with latencies consistent with known vestibulo-spinal pathways. Furthermore, while the evoked head movements were substantially smaller than the coincidently evoked eye movements, they made a significant contribution to gaze stabilization, complementing the VOR to ensure that the appropriate gaze response is achieved. We speculate that analogous compensatory head movements will be evoked when implanted prosthetic devices are transitioned to human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.