ArticlePloS one2013
Adherence to antiretroviral therapy in Jinja, Uganda: a six-year follow-up study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis.AIDS and behavior · 2017Pooled it
- Applying convergent parallel mixed methods design to investigate medication adherence among people living with HIV in resource-limited settings: methodological insights from Ghana.Frontiers in public health · 2026Article
- Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial).American heart journal · 2024Article
- Experiences of people living with HIV in low- and middle-income countries and their perspectives in self-management: a meta-synthesis.AIDS research and therapy · 2024Review
- Adherence to Antiretroviral Therapy and Its Predictive Factors Among People Living with HIV in China: A Behavioral Theory-Based Prospective Cohort Study.International journal of behavioral medicine · 2023Article
- Determinants of viral load non-suppression among adolescents in Mbale District, Eastern Rural Uganda.AIDS research and therapy · 2021Article
- Article
- Scaling-up PrEP Delivery in Sub-Saharan Africa: What Can We Learn from the Scale-up of ART?Current HIV/AIDS reports · 2019Review
- Are treatment supporters relevant in long-term Antiretroviral Therapy (ART) adherence? Experiences from a long-term ART cohort in Uganda.Global public health · 2019Article
- What causes non-adherence among some individuals on long term antiretroviral therapy? Experiences of individuals with poor viral suppression in Uganda.AIDS research and therapy · 2019Article
- Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance.AIDS and behavior · 2018Article
- Changing forms of HIV-related stigma along the HIV care and treatment continuum in sub-Saharan Africa: a temporal analysis.Sexually transmitted infections · 2017Article
- Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa.AIDS (London, England) · 2017Review
- The Framing and Fashioning of Therapeutic Citizenship Among People Living With HIV Taking Antiretroviral Therapy in Uganda.Qualitative health research · 2016Article
- Antiretroviral therapy initiation and adherence in rural South Africa: community health workers' perspectives on barriers and facilitators.AIDS care · 2016Article
- Association of knowledge on ART line of treatment, scarcity of treatment options and adherence.BMC health services research · 2016Article
- Understanding Sustained Retention in HIV/AIDS Care and Treatment: a Synthetic Review.Current HIV/AIDS reports · 2016Review
- Long-Term Antiretroviral Treatment Adherence in HIV-Infected Adolescents and Adults in Uganda: A Qualitative Study.PloS one · 2016Article
- Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: a systematic review.BMJ global health · 2016Article
- The Medical Research Council (UK)/Uganda Virus Research Institute Uganda Research Unit on AIDS--'25 years of research through partnerships'.Tropical medicine & international health : TM & IH · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionWe report on the adherence experience of a group of people living with HIV on ART over six years in Uganda.
methodsBetween 2005 and 2009, we followed up 41 participants who were also part of a clinical trial comparing home and facility based delivery of ART in Jinja, eastern Uganda. We conducted qualitative in-depth interviews at enrolment, 3, 6, 18 and 30 months to capture experiences with adherence over time. In 2011 we returned to these participants to find out how they were fairing with long term adherence. We managed to retrace 24 participants and interviewed them about their experience. We thematically analysed the data and compared findings over time.
resultsInitially there were few barriers to adherence and many followed the adherence guidance closely. By year six, relaxation of these rules was noticeable although self-reported adherence continued to be high. Alcohol consumption was more common than before. Some relatives of the participants who had died claimed that some deaths were a result of alcohol. While participants reported that ART had allowed them to reclaim independence and return to work the changes in work and social routines created new challenges for adherence. Side effects like lipodystrophy were not only causing some stigma but for some tested their faith in the drugs. Many participants reported resumption of sexual lives but apart from those who selected same status partners, disclosure to new partners was minimal.
conclusionGood adherence practice to ART wanes over the long-term, and people who may have disclosed at initiation find it difficult to do so to new partners once they are healthy. Further adherence interventions and support with disclosure over the course of therapy may need to be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.