ArticlePloS one2013
Fecal protease activity is associated with compositional alterations in the intestinal microbiota.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- Distinct Fecal Proteolytic Activity in Zoo Animals with Different Feeding Strategies.Animals : an open access journal from MDPI · 2025Article
- Comparative analysis of amino acid auxotrophies and peptidase profiles in non-dysbiotic and dysbiotic small intestinal microbiomes.Computational and structural biotechnology journal · 2025Article
- A triad of gut dysbiosis, dysregulated immunity, and 'leaky' gut characterize HCMV associated neonatal cholestasis.Gut pathogens · 2024Article
- A Bacteriophage Protein-Based Impedimetric Electrochemical Biosensor for the Detection ofBiosensors · 2024Article
- The Impact of Surgical Bowel Preparation on the Microbiome in Colon and Rectal Surgery.Antibiotics (Basel, Switzerland) · 2024Review
- Fecal virus transplantation has more moderate effect than fecal microbiota transplantation on changing gut microbial structure in broiler chickens.Poultry science · 2024Article
- Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients.Scientific reports · 2023Article
- Article
- Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection.Infection and immunity · 2022Article
- Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.Nature microbiology · 2022Article
- [Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
- SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice.Cells · 2021Article
- The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life.Journal of translational medicine · 2021Article
- A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment.Communications biology · 2020Article
- Comparison of protease and aminopeptidase activities in meconium: A pilot study.Biomedical reports · 2020Article
- Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS.Gut · 2020Article
- Effects of protease and phytase supplements on small intestinal microbiota and amino acid digestibility in broiler chickens.Poultry science · 2019Article
- Efficient Extraction from Mice Feces for NMR Metabolomics Measurements with Special Emphasis on SCFAs.Metabolites · 2019Article
- Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveIntestinal proteases carry out a variety of functions in the gastrointestinal (GI) tract. Studies have reported that elevated enteric proteases in patients with GI disease can alter intestinal physiology, however the origin (human vs. microbial) of elevated proteases in patients with GI disease is unclear.
aimThe aim of this study was to investigate the association between protease activity and the microbiota in human fecal samples.
designIn order to capture a wide range of fecal protease (FP) activity stool samples were collected from 30 IBS patients and 24 healthy controls. The intestinal microbiota was characterized using 454 high throughput pyro-sequencing of the 16S rRNA gene. The composition and diversity of microbial communities were determined and compared using the Quantitative Insights Into Microbial Ecology (QIIME) pipeline. FP activity levels were determined using an ELISA-based method. FP activity was ranked and top and bottom quartiles (n=13 per quartile) were identified as having high and low FP activity, respectively.
resultsThe overall diversity of the intestinal microbiota displayed significant clustering separation (p = 0.001) between samples with high vs. low FP activity. The Lactobacillales, Lachnospiraceae, and Streptococcaceae groups were positively associated with FP activity across the entire study population, whilst the Ruminococcaceae family and an unclassified Coriobacteriales family were negatively associated with FP activity.
conclusionsThese data demonstrate significant associations between specific intestinal bacterial groups and fecal protease activity and provide a basis for further causative studies investigating the role of enteric microbes and GI diseases.
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