ArticlePloS one2013
T2* "susceptibility vessel sign" demonstrates clot location and length in acute ischemic stroke.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02476188 (Neutrophil Extracellular Traps and Thrombolysis in the Acute Stroke), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neutrophil Extracellular Traps and Thrombolysis in the Acute Stroke
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Value of thrombus imaging in predicting the outcomes of patients with large-vessel occlusive strokes after endovascular therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy : A Secondary Analysis of the SWIFT DIRECT Trial.Clinical neuroradiology · 2025Trial
- Relationships between brain perfusion and early recanalization after intravenous thrombolysis for acute stroke with large vessel occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Susceptibility Vessel Sign and Cardioembolic Etiology in the THRACE Trial.Clinical neuroradiology · 2019Trial
- Validation of overestimation ratio and TL-SVS as imaging biomarker of cardioembolic stroke and time from onset to MRI.European radiology · 2019Trial
- The comparison of MRI and CT protocol examination times for mechanical thrombectomy in acute ischemic stroke.Radiological physics and technology · 2025Article
- Ironing out differences in attenuation and blooming artifact in acute stroke thrombi.Scientific reports · 2025Article
- A retrospective study of the Dual-channels Bolus Contrast Injection (Dc-BCI) technique during endovascular mechanical thrombectomy in the management of acute ischemic stroke due to large-vessel occlusion: a technical report.Frontiers in neurology · 2025Article
- Frictional forces in stent retriever procedures: The impact of vessel diameter, angulation, and deployment position.Surgical neurology international · 2024Article
- Hyperacute treatment of childhood stroke in Lyme neuroborreliosis: report of two cases and systematic review of the literature.Therapeutic advances in neurological disorders · 2022Article
- Risks of Undersizing Stent Retriever Length Relative to Thrombus Length in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2021Article
- In Vitro Study of Blood Clot Identification and Composition Assessment by Different Magnetic Resonance Sequences.Cureus · 2021Article
- Impact of Clot Shape on Successful M1 Endovascular Reperfusion.Frontiers in neurology · 2021Article
- Accuracy of MRI T2*-weighted sequences (GRE-EPI) compared to CTA for detection of anterior circulation large vessel thrombus.Emergency radiology · 2020Article
- Characterization of clot composition in acute cerebral infarct using machine learning techniques.Annals of clinical and translational neurology · 2019Article
- Does Clot Burden Score on Baseline T2*-MRI Impact Clinical Outcome in Acute Ischemic Stroke Treated with Mechanical Thrombectomy?Journal of stroke · 2019Article
- MRI Quantitative T2* Mapping to Predict Dominant Composition of In Vitro Thrombus.AJNR. American journal of neuroradiology · 2019Article
- Characteristic Signs on T2*-Based Imaging and Their Relationship with Results of Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Evidence to Date.Neurointervention · 2018Article
- Revisiting 'progressive stroke': incidence, predictors, pathophysiology, and management of unexplained early neurological deterioration following acute ischemic stroke.Journal of neurology · 2018Article
- Susceptibility vessel sign predicts poor clinical outcome for acute stroke patients untreated by thrombolysis.Experimental and therapeutic medicine · 2017Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of our study was to evaluate, in acute ischemic stroke patients, the diagnostic accuracy of the MRI susceptibility vessel sign (SVS) against catheter angiography (DSA) for the detection of the clot and its value in predicting clot location and length. MATERIALS AND
methodsWe identified consecutive patients (2006-2012) admitted to our center, where 1.5 T MRI is systematically implemented as first-line diagnostic work-up, with: (1) pre-treatment 6-mm-thick multislice 2D T2* sequence; (2) delay from MRI-to-DSA <3 hrs; (3) no fibrinolysis between MRI and DSA. The location and length of SVS on T2* was independently assessed by three readers, and compared per patient, per artery and per segment, to DSA findings, obtained by two different readers. Clot length measured on T2* and DSA were compared using intra-class correlation coefficient (ICC), Bland & Altman test and Passing & Bablok regression analysis.
resultsOn DSA, a clot was present in 85 patients, in 126 of 1190 (10.6%) arteries and 175 of 1870 (9.4%) segments. Sensitivity of the SVS, as sensed by the used protocol at 1.5 T, was 81.1% (69 of 85 patients) and was higher in anterior (55 of 63, 87.3%), than in posterior circulation stroke (14 of 22, 63.6%, p=0.02). Sensitivity/specificity was 69.8/99.6% (per artery) and 76.6/99.7% (per segment). Positive (PPV) and negative predictive value (NPV) and accuracy were all >94%. Inter- and intra-observer ICC was excellent for clot length as measured on T2* (ĸ ≥ 0.97) and as measured on DSA (ĸ ≥ 0.94). Correlation between T2* and DSA for clot length was excellent (ICC: 0.88, 95%CI: 0.81-0.92; Bland & Altman: mean bias of 1.6% [95%CI: -4.7 to 7.8%], Passing & Bablok: 0.91).
conclusionsSVS is a specific marker of clot location in the anterior and posterior circulation. Clot length greater than 6 mm can be reliably measured on T2*.
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