ArticlePloS one2013
The association between the levels of serum ferritin and sex hormones in a large scale of Chinese male population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Relationship between Iron Deficiency and Thyroid Function: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Dietary patterns and testosterone balance: a review of clinical data and perspectives.Journal of advanced research · 2026Review
- Biomarkers of Iron Are Associated with Anterior-Pituitary-Produced Reproductive Hormones in Men with Infertility.Nutrients · 2024Article
- Sex difference in the association between blood alcohol concentration and serum ferritin.Frontiers in psychiatry · 2023Article
- The Clinical Utility of ABO and RHD Systems as Potential Indicators of Health Status, a Preliminary Study in Greek Population.Clinics and practice · 2022Article
- Waist-to-height ratio, an optimal anthropometric indicator for metabolic dysfunction associated fatty liver disease in the Western Chinese male population.Lipids in health and disease · 2021Article
- Prevalence of Iron deficiency in Lebanese schoolchildren.European journal of clinical nutrition · 2020Article
- Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity.Antioxidants (Basel, Switzerland) · 2020Article
- Testosterone-Associated Dietary Pattern Predicts Low Testosterone Levels and Hypogonadism.Nutrients · 2018Article
- The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women.PloS one · 2018Article
- Serum ferritin and primary lung cancer.Oncotarget · 2017Article
- Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults.PloS one · 2017Article
- High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population.Diabetology & metabolic syndrome · 2015Article
- Serum Ferritin Is Inversely Correlated with Testosterone in Boys and Young Male Adolescents: A Cross-Sectional Study in Taiwan.PloS one · 2015Article
- Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population.PloS one · 2014Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ferritin is an important participant of iron-storage but its regulation and related factors were not well defined. The present objective was to explore the potential association between serum ferritin levels and sex hormones.
methods1999 Chinese men in the Fangchenggang Area Male Health and Examination Survey (FAMHES) were recruited in this cross-sectional study. Levels of serum ferritin, total testosterone (free testosterone was calculated from the total one), estradiol and sex hormone-binding protein were detected in venous blood samples. The effects of age, BMI, smoking as well as alcohol consumption were analyzed on ferritin levels, respectively, and then the Pearson's correlation analysis was used to evaluate the association between ferritin levels and sex hormones adjusting for the above factors.
resultsThe age, BMI and alcohol consumption significantly affected serum ferritin levels, but there was no significant difference between smokers and nonsmokers. Ferritin levels were significantly and negatively associated with total testosterone (R = -0.205, P< 0.001), sex hormone-binding protein (R = -0.161, P<0.001) and free testosterone (R = -0.097, P<0.001). After age and alcohol consumption were adjusted, the above associations were still significant (R = -0.200, -0.181 and -0.083, respectively, all P<0.001). However, there was only borderline negative association between ferritin levels and estradiol (adjusted R = -0.039, P = 0.083).
conclusionThe large scale of epidemic results showed the significantly negative associations between serum ferritin levels and sex hormones, which may provide more clues to explore the potential regulation and biological mechanism of ferritin.
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