ReviewFrontiers in endocrinology2013
Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance.
Review in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Melanin concentrating hormone regulates bone cell activities and calcium metabolism in regenerating goldfish scales.Scientific reports · 2026Article
- Understanding peptide hormones: from precursor proteins to bioactive molecules.Trends in biochemical sciences · 2025Review
- A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System.Biomedicines · 2025Review
- Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses.Frontiers in endocrinology · 2025Article
- The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (eLife · 2024Article
- Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain.The Journal of comparative neurology · 2023Article
- Light conditions during Atlantic salmon embryogenesis affect key neuropeptides in the melanocortin system during transition from endogenous to exogenous feeding.Frontiers in behavioral neuroscience · 2023Article
- Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.International journal of molecular sciences · 2022Article
- Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism.Frontiers in physiology · 2022Article
- Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary.International journal of molecular sciences · 2021Article
- Chemokine CXCL14-like immunoreactivity in the αMSH-producing cells and PRL-producing cells of the flat-tailed house gecko pituitary.The Journal of veterinary medical science · 2020Article
- Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Review
- Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound.Frontiers in endocrinology · 2016Review
- The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Posttranslational modification of intercellular messenger systems.Frontiers in endocrinology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation, glycosylation, and disulfide linkage formation, which generate mature POMC-derived peptides. Therefore, POMC is a useful model for the investigation of posttranslational modifications. These processes have been extensively investigated in mammals, primarily in rodents. In addition, over the last decade, much information has been obtained about the posttranslational processing of POMC in non-mammalian animals such as fish, amphibians, reptiles, and birds through sequencing and peptide identification by mass spectrometry. One POMC modification, acetylation, is known to modulate the biological activities of POMC-derived α-melanocyte-stimulating hormone (α-MSH) having an acetyl group at N-terminal through potentiation or inhibition. This bidirectional regulation depends on its intrinsic roles in the tissue or cell; for example, α-MSH, as well as desacetyl (Des-Ac)-α-MSH, stimulates pigment dispersion in the xanthophores of a flounder. In contrast, α-MSH does not stimulate pigment dispersion in the melanophores of the same species, whereas Des-Ac-α-MSH does. Regulation of pigment-dispersing activities may be associated with the subtle balance in the expression of receptor genes. In this review, we consider the posttranslational modifications of POMC in vertebrates from an evolutionary aspect, with a focus on the relationship between acetylation and the biological activities of α-MSH as an important consequence of posttranslational modification.
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