ReviewPLoS genetics2013
A review of bacteria-animal lateral gene transfer may inform our understanding of diseases like cancer.
Review in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Magnetic medical microrobots with memory-capable genetic circuits.Science advances · 2026Article
- The authors respond to feedback onFrontiers in oncology · 2026Article
- Human long non-coding RNAs acquired from bacteria via horizontal gene transfer promote gallbladder cancer.Molecular biology reports · 2025Article
- Engineered bacteria detect tumor DNA.Science (New York, N.Y.) · 2023Article
- hgtseq: A Standard Pipeline to Study Horizontal Gene Transfer.International journal of molecular sciences · 2022Article
- Review
- Detecting Bacterial-Human Lateral Gene Transfer in Chronic Lymphocytic Leukemia.International journal of molecular sciences · 2022Article
- Article
- Gene Duplications Are At Least 50 Times Less Frequent than Gene Transfers in Prokaryotic Genomes.Genome biology and evolution · 2021Article
- Role of Bacteria in the Incidence of Common GIT Cancers: The Dialectical Role of Integrated Bacterial DNA in Human Carcinogenesis.Infection and drug resistance · 2021Review
- Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression.Frontiers in cell and developmental biology · 2020Review
- LEMON: a method to construct the local strains at horizontal gene transfer sites in gut metagenomics.BMC bioinformatics · 2019Article
- Symbiosis Comes of age at the 10Applied and environmental microbiology · 2019Review
- Patterns and mechanisms of structural variations in human cancer.Experimental & molecular medicine · 2018Review
- Functional horizontal gene transfer from bacteria to eukaryotes.Nature reviews. Microbiology · 2018Review
- Genomic Features of the Damselfly Calopteryx splendens Representing a Sister Clade to Most Insect Orders.Genome biology and evolution · 2017Article
- Potential Effects of Horizontal Gene Exchange in the Human Gut.Frontiers in immunology · 2017Article
- Article
- Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia.Scientific reports · 2016Article
- Transfer of DNA from Bacteria to Eukaryotes.mBio · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Lateral gene transfer (LGT) from bacteria to animals occurs more frequently than was appreciated prior to the advent of genome sequencing. In 2007, LGT from bacterial Wolbachia endosymbionts was detected in ~33% of the sequenced arthropod genomes using a bioinformatic approach. Today, Wolbachia/host LGT is thought to be widespread and many other cases of bacteria-animal LGT have been described. In insects, LGT may be more frequently associated with endosymbionts that colonize germ cells and germ stem cells, like Wolbachia endosymbionts. We speculate that LGT may occur from bacteria to a wide variety of eukaryotes, but only becomes vertically inherited when it occurs in germ cells. As such, LGT may happen routinely in somatic cells but never become inherited or fixed in the population. Lack of inheritance of such mutations greatly decreases our ability to detect them. In this review, we propose that such noninherited bacterial DNA integration into chromosomes in human somatic cells could induce mutations leading to cancer or autoimmune diseases in a manner analogous to mobile elements and viral integrations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.