ArticleBiomechanics and modeling in mechanobiology2014
Dynamic permeability of the lacunar-canalicular system in human cortical bone.
Article in Biomechanics and modeling in mechanobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Effects on Mass Transfer in the Bone Lacunar-Canalicular System under Different Radial Extracorporeal Shock Waves.Tissue engineering and regenerative medicine · 2025Article
- Adaptable test bench for ASTM-compliant permeability measurement of porous scaffolds for tissue engineering.Scientific reports · 2024Article
- Effects of Osteocyte Shape on Fluid Flow and Fluid Shear Stress of the Loaded Bone.BioMed research international · 2022Article
- Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone.Journal of biomechanics · 2018Article
- Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.Bone reports · 2017Article
- [Research advances of fluid bio-mechanics in bone].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Review
- Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Predicting cortical bone adaptation to axial loading in the mouse tibia.Journal of the Royal Society, Interface · 2015Article
- Blood and interstitial flow in the hierarchical pore space architecture of bone tissue.Journal of biomechanics · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A new method for the experimental determination of the permeability of a small sample of a fluid-saturated hierarchically structured porous material is described and applied to the determination of the lacunar-canalicular permeability [Formula: see text] in bone. The interest in the permeability of the lacunar-canalicular pore system (LCS) is due to the fact that the LCS is considered to be the site of bone mechanotransduction due to the loading-driven fluid flow over cellular structures. The permeability of this space has been estimated to be anywhere from [Formula: see text] to [Formula: see text]. However, the vascular pore system and LCS are intertwined, rendering the permeability of the much smaller-dimensioned LCS challenging to measure. In this study, we report a combined experimental and analytical approach that allowed the accurate determination of the [Formula: see text] to be on the order of [Formula: see text] for human osteonal bone. It was found that the [Formula: see text] has a linear dependence on loading frequency, decreasing at a rate of [Formula: see text]/Hz from 1 to 100 Hz, and using the proposed model, the porosity alone was able to explain 86 % of the [Formula: see text] variability.
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